Reactome | SOCS4 [cytosol]

SOCS4 [cytosol]

Stable Identifier

R-HSA-8936109

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Suppressor of cytokine signaling 4, SOCS4_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9BXM7 PINK1

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates transcription of genes involved in differentiation of keratinocytes (Homo sapiens)
        
        SOCS4 gene expression is inhibited by RUNX1 (Homo sapiens)
        
        SOCS4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WXH5 SOCS4

Gene Names

SOCS4, SOCS7

Chain

chain:1-440

Reference Genes

BioGPS Gene:122809 SOCS4

COSMIC (genes):SOCS4 SOCS4

CTD Gene:122809 SOCS4

dbSNP Gene:122809 SOCS4

ENSEMBL:ENSG00000180008 SOCS4

HGNC:19392 SOCS4

KEGG:hsa:122809 SOCS4

Monarch:122809 SOCS4

NCBI Gene:122809 SOCS4

OMIM:616337 SOCS4

UCSC:Q8WXH5 SOCS4

Reference Transcript

Other Identifiers

11736895_s_at

11739980_a_at

11739981_s_at

11752167_a_at

122809

1552792_PM_at

1552792_at

16784367

226178_PM_at

226178_at

3536651

3536652

3536653

3536654

3536656

3536657

3536658

3536659

3536660

3536661

3536662

3536664

3536665

3536666

3536667

3536668

45116_at

7974447

A_14_P114190

A_14_P124778

A_23_P151700

A_24_P90637

A_33_P3349334

GE514642

GE563681

GE870991

GO:0005515

GO:0005942

GO:0006629

GO:0007175

GO:0009968

GO:0016567

GO:0032436

GO:0035556

GO:0046854

GO:0046935

GO:0098772

HMNXSV003036863

Hs.34789.1.A1_3p_at

Hs2.352327.1.S1_3p_at

ILMN_1753795

ILMN_2413259

ILMN_2413264

PH_hs_0016858

PH_hs_0029833

TC14000321.hg

Participates

as an output of

SOCS4 gene expression is inhibited by RUNX1 (Homo sapiens)

Cross References

OpenTargets

ENSG00000180008

ENSEMBL

ENST00000395472, ENSP00000378855, ENSP00000452522, ENST00000555846, ENST00000339298, ENSP00000341327

HPA

ENSG00000180008-SOCS4

PRO

Q8WXH5

Pharos - Targets

Q8WXH5

PDB

2IZV

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.57	3
UniProt:Q9BXM7 PINK1	5	PINK1(111-581) [mitochondrial intermembrane space] (R-HSA-5205628) PINK1 [cytosol] (R-HSA-5205637) PINK1 [mitochondrial intermembrane space] (R-HSA-5205671) PINK1 [mitochondrial outer membrane] (R-HSA-5205653) p-S228,S402-PINK1 [mitochondrial outer membrane] (R-HSA-9834051)	0.57	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.57	3
UniProt:Q96R05 RET7			0.57	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:O43464 HTRA2	1	HTRA2 [mitochondrial intermembrane space] (R-HSA-56655)	0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:Q9BZ23-2 PANK2			0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:O15269-2 O152692			0.556	3
UniProt:P41250 GARS1	2	GARS [mitochondrial matrix] (R-HSA-379650) GARS(55-739) [cytosol] (R-HSA-379574)	0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:J3KQ12 J3KQ12			0.556	3
UniProt:Q8WW24 TEKT4			0.556	3
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.527	3
UniProt:O43559 FRS3	3	p-5Y-FRS3 [plasma membrane] (R-HSA-191475) FRS3 [plasma membrane] (R-HSA-191482) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.508	2
UniProt:Q9BYZ2 LDHAL6B	1	LDHAL6B [mitochondrial matrix] (R-HSA-6807613)	0.488	2
UniProt:Q8N3R9 MPP5	2	MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9689606) MPP5 [plasma membrane] (R-HSA-419969)	0.488	2
IntAct:EBI-10696539 PPAPDC2			0.488	2
UniProt:Q07912 TNK2	1	TNK2 [cytosol] (R-HSA-9842568)	0.488	2
UniProt:O75829-2 CNMD			0.488	2

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