Reactome | ARNT2 [nucleoplasm]

ARNT2 [nucleoplasm]

Stable Identifier

R-HSA-8936838

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Aryl hydrocarbon receptor nuclear translocator 2, ARNT2_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q86UW9 DTX2

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by NPAS4 (Homo sapiens)
      - NPAS4 regulates expression of target genes (Homo sapiens)
        
        NPAS4 binds ARNT2 (Homo sapiens)
        
        ARNT2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HBZ2 ARNT2

Gene Names

ARNT2, BHLHE1, KIAA0307

Chain

chain:1-717

Reference Genes

BioGPS Gene:9915 ARNT2

COSMIC (genes):ARNT2 ARNT2

CTD Gene:9915 ARNT2

dbSNP Gene:9915 ARNT2

ENSEMBL:ENSG00000172379 ARNT2

ENSEMBL_homo_sapiens_GENE:ENSG00000172379.22 ARNT2

HGNC:16876 ARNT2

KEGG Gene (Homo sapiens):9915 ARNT2

Monarch:9915 ARNT2

NCBI Gene:9915 ARNT2

OMIM:606036 ARNT2

UCSC:Q9HBZ2 ARNT2

Reference Transcript

RefSeq:NM_014862.3 ARNT2

Other Identifiers

11735058_a_at

11748737_a_at

11762216_x_at

16803710

202986_PM_at

202986_at

35352_at

3604007

3604008

3604009

3604010

3604012

3604023

3604024

3604027

3604036

3604040

3604041

3604046

3604047

3604048

3604051

3604054

3604056

3604057

3604061

3604062

3604064

3604065

3604072

3604073

3604075

3604076

3604077

3604078

7985285

9915

A_14_P105294

A_14_P139356

A_33_P3366195

GE53046

GO:0000785

GO:0000978

GO:0000981

GO:0001228

GO:0001666

GO:0001701

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0006351

GO:0006355

GO:0006357

GO:0007417

GO:0007420

GO:0017162

GO:0034751

GO:0043226

GO:0045893

GO:0045944

GO:0046982

GO:0046983

GO:0048856

GO:0140110

GO:1990837

HMNXSV003050230

ILMN_1718046

PH_hs_0000618

TC15000749.hg

g7662049_3p_s_at

Participates

as a member of

ARNT, ARNT2 [nucleoplasm] (Homo sapiens)

as an input of

NPAS4 binds ARNT2 (Homo sapiens)

as a component of

NPAS4:ARNT2 [nucleoplasm] (Homo sapiens)

Inferred To

Arnt2 [nucleoplasm] (Mus musculus)

Arnt2 [nucleoplasm] (Rattus norvegicus)

ARNT2 [nucleoplasm] (Bos taurus)

ARNT2 [nucleoplasm] (Canis familiaris)

ARNT2 [nucleoplasm] (Gallus gallus)

ARNT2 [nucleoplasm] (Sus scrofa)

arnt2 [nucleoplasm] (Danio rerio)

arnt2 [nucleoplasm] (Xenopus tropicalis)

aha-1 [nucleoplasm] (Caenorhabditis elegans)

tgo [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_055677.3

OpenTargets

ENSG00000172379

GeneCards

Q9HBZ2

HPA

ENSG00000172379-ARNT2

Ensembl

ENST00000303329, ENST00000527771, ENSP00000307479, ENSG00000172379, ENSP00000453792, ENST00000533983, ENSP00000453651

PRO

Q9HBZ2

Pharos - Targets

Q9HBZ2

Orphanet

22563

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q86UW9 DTX2	1	DTX2 [cytosol] (R-HSA-1604436)	0.666	4
UniProt:Q9UJX0 OSGI1			0.556	3
UniProt:P81133 SIM1			0.556	3
UniProt:P25791-3 LMO2			0.556	3
UniProt:Q9BXS5 AP1M1	7	AP1M1 [cytoplasmic vesicle membrane] (R-HSA-351196) AP1M1 [Golgi membrane] (R-HSA-350805) AP1M1 [lysosomal membrane] (R-HSA-432708) AP1M1 [trans-Golgi network membrane] (R-HSA-2130512) AP1M1 [cytosol] (R-HSA-167700) AP1M1 [plasma membrane] (R-HSA-6806311) AP1M1 [specific granule membrane] (R-HSA-6799365)	0.556	3
UniProt:O75716 STK16			0.556	3
UniProt:Q9Y6W3 CAPN7	1	CAPN7 [cytosol] (R-HSA-8848633)	0.556	3
UniProt:P61968 LMO4			0.556	3
UniProt:Q6NZ36-4 FAAP20			0.556	3
UniProt:Q9Y2T2 AP3M1	1	AP3M1 [cytosol] (R-HSA-391288)	0.556	3
UniProt:P20618 PSMB1	7	PSMB1(1-28) [cytosol] (R-HSA-9908143) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [cytosol] (R-HSA-68738)	0.556	3
UniProt:Q8IXF0 NPAS3			0.547	3
UniProt:Q9BUZ4 TRAF4			0.547	2
UniProt:Q16665 HIF1A	7	HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.547	2

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