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AIP [cytosol]
Stable Identifier
R-HSA-8936839
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
AH receptor-interacting protein, AIP_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
Expression of Aryl Hydrocarbon receptor-interacting protein (Homo sapiens)
AIP [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Aryl hydrocarbon receptor signalling (Homo sapiens)
AHR:2xHSP90:AIP:PTGES3 binds TCDD (Homo sapiens)
AHR:2xHSP90AB1:AIP:PTGES3 [cytosol] (Homo sapiens)
AIP [cytosol] (Homo sapiens)
AHR:TCDD:2xHSP90AB1:AIP:PTGES3 [cytosol] (Homo sapiens)
AHR:2xHSP90AB1:AIP:PTGES3 [cytosol] (Homo sapiens)
AIP [cytosol] (Homo sapiens)
AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm (Homo sapiens)
AHR:TCDD:2xHSP90AB1:AIP:PTGES3 [cytosol] (Homo sapiens)
AHR:2xHSP90AB1:AIP:PTGES3 [cytosol] (Homo sapiens)
AIP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00170 AIP
Gene Names
AIP, aryl hydrocarbon receptor interacting protein, XAP2
Chain
chain:1-330
Reference Genes
BioGPS Gene:9049 AIP
COSMIC (genes):AIP AIP
CTD Gene:9049 AIP
dbSNP Gene:9049 AIP
ENSEMBL:ENSG00000110711 AIP
ENSEMBL_homo_sapiens_GENE:ENSG00000110711.11 AIP
HGNC:358 AIP
KEGG Gene (Homo sapiens):9049 AIP
Monarch:9049 AIP
NCBI Gene:9049 AIP
OMIM:605555 AIP
UCSC:O00170 AIP
Reference Transcript
RefSeq:NM_003977.3 AIP
RefSeq:NM_001302960.1 AIP
RefSeq:NM_001302959.1 AIP
Other Identifiers
11715980_at
16727908
201781_PM_s_at
201781_s_at
201782_PM_s_at
201782_s_at
3337140
3337141
3337142
3337145
3337147
3337149
3337150
3337152
3337153
36586_at
7941927
9049
GO:0003712
GO:0003713
GO:0003755
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006457
GO:0006626
GO:0006805
GO:0006886
GO:0007005
GO:0010738
GO:0016020
GO:0016853
GO:0017162
GO:0022417
GO:0023052
GO:0034751
GO:0036004
GO:0043226
GO:0045893
GO:0051082
GO:0051604
GO:0140096
GO:0140110
HMNXSV003056212
Hs.75305.0.S1_3p_a_at
ILMN_2103841
PH_hs_0024902
PH_hs_0035930
TC11000693.hg
U78521_at
Participates
as an output of
Expression of Aryl Hydrocarbon receptor-interacting protein (Homo sapiens)
as a component of
AHR:2xHSP90AB1:AIP:PTGES3 [cytosol] (Homo sapiens)
Other forms of this molecule
AIP [nucleoplasm]
Inferred To
AIP [cytosol]
(Bos taurus)
AIP [cytosol]
(Canis familiaris)
AIP [cytosol]
(Dictyostelium discoideum)
AIP [cytosol]
(Gallus gallus)
AIP [cytosol]
(Plasmodium falciparum)
AIP [cytosol]
(Sus scrofa)
Dmel\CG1847 [cytosol]
(Drosophila melanogaster)
aipr-1 [cytosol]
(Caenorhabditis elegans)
Aip [cytosol]
(Mus musculus)
Aip [cytosol]
(Rattus norvegicus)
aip [cytosol]
(Danio rerio)
aip [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001289888.1
,
NP_001289889.1
,
NP_003968.3
OpenTargets
ENSG00000110711
HPA
ENSG00000110711-AIP
GeneCards
O00170
Ensembl
ENSP00000279146
,
ENSG00000110711
,
ENST00000279146
PRO
O00170
Pharos - Targets
O00170
Orphanet
18425
PDB
4APO
,
8QMO
,
7ZUB
,
2LKN
,
4AIF
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.829
8
UniProt:P50750 CDK9
1
CDK9 [nucleoplasm]
(R-HSA-51801)
0.643
5
UniProt:O00408 PDE2A
1
PDE2A [cytosol]
(R-HSA-418499)
0.602
6
UniProt:P68400 CSNK2A1
2
CSNK2A1 [nucleoplasm]
(R-HSA-6805057)
CSNK2A1 [cytosol]
(R-HSA-201713)
0.59
2
UniProt:O60809 PRA10
0.589
2
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:Q6PHR2 ULK3
1
ULK3 [ciliary tip]
(R-HSA-5635039)
0.527
2
UniProt:P13385 TDGF1
1
N-aspartyl-glycosylphosphatidylinositolethanolamine-TDGF1(31-188) [plasma membrane]
(R-HSA-452300)
0.527
3
UniProt:Q96HB5 CC120
0.527
4
UniProt:Q5VTA0 PRA17
0.527
2
UniProt:Q15185 PTGES3
2
PTGES3 [nucleoplasm]
(R-HSA-5082403)
PTGES3 [cytosol]
(R-HSA-265269)
0.527
2
UniProt:Q0VAF6 SYCN
0.499
2
UniProt:Q92985 IRF7
5
K63polyUb-IRF7 [endosome membrane]
(R-HSA-975154)
IRF7 [endosome membrane]
(R-HSA-450274)
p-S477,S479-IRF7 [nucleoplasm]
(R-HSA-450270)
p-S477,S479-IRF7 [cytosol]
(R-HSA-450318)
IRF7 [cytosol]
(R-HSA-450281)
0.499
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
8
UniProt:P35869 AHR
2
AHR [cytosol]
(R-HSA-8936842)
AHR [nucleoplasm]
(R-HSA-8937190)
0.463
3
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