Reactome | CRHBP binds CRH

CRHBP binds CRH

Stable Identifier

R-HSA-8937613

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Corticoliberin (CRH, aka corticotropin-releasing factor CRF) is a 41-amino acid amino peptide which, together with CRH-related peptides such as the urocortins (UCNs), play a role in coordinating endocrine, autonomic and behavioural responses to stress. These peptides exert their effects through binding and activation of two class B/Secretin family of GPCRs, CRHR1 and CRHR2 (aka CRFR1 and CRFR2 respectively). The corticotropin-releasing factor-binding protein (CRHBP) can bind to CRH with high affinity, inactivating it. CRHBP is expressed in the brains of all species examined to date but is uniquely expressed in human liver and placenta. In the brain, CRHBP is located in pituitary corticotropes, where it is under positive glucocorticoid control, and is likely to locally modulate CRH-induced ACTH secretion (Behan et al. 1993, Behan et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
8198617	Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP) Lowry, PJ, Lewis, KA, Vale, WW, Copeland, N, Potter, E, Jenkins, NA, Behan, DP	Genomics	1993
8557170	Corticotropin releasing factor (CRF) binding protein: a novel regulator of CRF and related peptides Lowry, PJ, Vale, WW, Potter, E, De Souza, EB, Sawchenko, P, Behan, DP	Front Neuroendocrinol	1995