SRC phosphorylates RUNX3

Stable Identifier
R-HSA-8937807
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SRC phosphorylates RUNX3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated SRC phosphorylates RUNX3 in the cytosol, on multiple tyrosine residues. There are eleven tyrosine residues in RUNX3, but SRC target sites have not been determined. SRC-mediated phosphorylation of RUNX3 inhibits translocation of RUNX3 to the nucleus and is the underlying cause of cytosolic localization of RUNX3 in gastric and breast cancer (Goh et al. 2010).
Literature References
PubMed ID Title Journal Year
20100835 Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm

Cinghu, S, Lee, KS, Lee, YS, Kim, JH, Goh, YM, Hong, ET, Bae, SC, Jang, JW, Ito, Y, Chi, XZ, Oh, BC, Li, YH, Wee, H

J. Biol. Chem. 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of MyrG-p-Y419-SRC:RUNX3 [plasma membrane]

Physical Entity
MyrG-p-Y419-SRC:RUNX3 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
SRC phosphorylates RUNX3 (Bos taurus)
SRC phosphorylates RUNX3 (Caenorhabditis elegans)
SRC phosphorylates RUNX3 (Canis familiaris)
SRC phosphorylates RUNX3 (Danio rerio)
SRC phosphorylates RUNX3 (Drosophila melanogaster)
SRC phosphorylates RUNX3 (Gallus gallus)
SRC phosphorylates RUNX3 (Mus musculus)
SRC phosphorylates RUNX3 (Rattus norvegicus)
SRC phosphorylates RUNX3 (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-12-13)
Reviewed
Ito, Y  (2017-01-31)
Chuang, LS  (2017-01-31)
Created
Orlic-Milacic, M  (2016-09-06)
Cite Us!