Reactome | RUNX1 binds PRC1 complexes

RUNX1 binds PRC1 complexes

Stable Identifier

R-HSA-8937989

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The RUNX1:CBFB complex associates with the polycomb repressor complex 1 (PRC1), including components of the PRC1.4 complex (the defining subunit being BMI1) and the PRC1.5 complex (the defining subunit being PCGF5). It is possible that the RUNX1:CBFB can also associate with other PRC1 complexes. PRC1 complexes are recruited to many RUNX1:CBFB target promoters and they either positively or negatively affect the transcription of RUNX1 target genes. The definitive composition of RUNX1:CBFB:PRC1 complexes at different RUNX1 target promoters has not been determined (Yu et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
22325351	Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors Roeder, RG, Kathrein, KL, Taniuchi, I, Huang, HT, Yu, M, Chouinard, CR, Woo, AJ, Akie, TE, Zacharek, S, Cantor, AB, Xie, H, Mazor, T, Labadorf, A, Kim, CF, Zon, LI, Huang, H, Fraenkel, E, Moran, TB	Mol. Cell	2012