SERPINB13 gene expression is inhibited by RUNX1:CBFB

Stable Identifier
R-HSA-8938063
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, lysosomal lumen
ReviewStatus
5/5
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SERPINB13 gene expression is inhibited by RUNX1:CBFB
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Binding of the RUNX1:CBFB complex to the promoter of the SERPINB13 gene inhibits SERPINB13 transcription and results in higher cathepsin K activity in cells, as SERPINB13 is an inhibitor of cathepsin K and L. Cathepsin K and L are associated with proliferation and invasiveness of cancer cells (Nomura and Katunuma 2005). SERPINB13 is frequently downregulated in head and neck cancers (Boyapati et al. 2011).
Literature References
PubMed ID Title Journal Year
21723253 SERPINB13 is a novel RUNX1 target gene

Boyapati, A, Ren, B, Zhang, DE

Biochem. Biophys. Res. Commun. 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
RUNX1:CBFB:SERPINB13 gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX1:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-09-08)
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