CD38 hydrolyses NAD+ to NAM and ADP-ribose

Stable Identifier
Reaction [transition]
Homo sapiens
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ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) is a multifunctional enzyme that can catalyse the hydrolysis of NAD+ to form linear ADP-ribose (ADP-D-ribose) and/or cyclization of NAD+ forming cyclic ADP-ribose (cADPR) via a two-step enzymatic reaction. The first common step involves the cleavage of the nicotinamide group of NAD+. The reaction intermediate can either be hydrolysed to form ADP-D-ribose or cyclized to form cADPR (Lee et al. 1995, Moreschi et al. 2006). CD38 can also produce nicotinic acid adenine dinucleotide phosphate (NAADP) (Lee et al. 1999). Both cADPR and NAADP are established second messengers for mobilising intracellular Ca2+ stores (Lee 2012). The reaction annotated here describes the hydrolysis of NAD+ to form ADP-D-ribose.
Literature References
PubMed ID Title Journal Year
22822066 Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilization

Lee, HC

J. Biol. Chem. 2012
10331643 Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes

Graeff, R, Lee, HC, Munshi, C

Mol. Cell. Biochem. 1999
8527488 Cyclic ADP-ribose and its metabolic enzymes

Graeff, R, Walseth, TF, Lee, HC

Biochimie 1995
16690024 NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases

Moreschi, I, Zocchi, E, Melone, L, Bruzzone, S, De Flora, A

Biochem. Biophys. Res. Commun. 2006
Catalyst Activity

NAD+ nucleotidase, cyclic ADP-ribose generating activity of CD38 [plasma membrane]

Orthologous Events
Cross References
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