Reactome | SERPINB13 binds cathepsin L

SERPINB13 binds cathepsin L

Stable Identifier

R-HSA-8938108

Type

Reaction [binding]

Species

Homo sapiens

Compartment

lysosomal lumen

ReviewStatus

5/5

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SERPINB13 binds the lysosomal cystein protease cathepsin L and inhibits its catalytic activity (Jayakumar et al. 2003, Welss et al. 2003). It is uncertain whether SERPINB13 functions in the lysosomes or exclusively in the cytosol, where it would inhibit the enzymatic activity of ectopic cathepsin L (Welss et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12809493	Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis Ruzicka, T, von Mikecz, A, Abts, HF, Irving, JA, Smith, AI, Blum, R, Sun, J, Whisstock, JC, Pike, RN, Welss, T, Bird, PI	Biochemistry	2003
12504904	Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis Brömme, D, Silverman, GA, Jayakumar, A, Clayman, GL, Kang, Y, Pak, SC, Henderson, Y, Holton, PR, EL-Naggar, AK, Mitsudo, K, Frederick, MJ	Arch. Biochem. Biophys.	2003