Reactome | RNF144A [endosome membrane]

RNF144A [endosome membrane]

Stable Identifier

R-HSA-8938771

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

E3 ubiquitin-protein ligase RNF144A ecNumber6.3.2.-/ecNumber, R144A_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q07065 CKAP4

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Literature References

PubMed ID	Title	Journal	Year
26216882	Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane Domain Lin, WC, Ho, SR, Lee, YJ	J. Biol. Chem.	2015

External Reference Information

External Reference

UniProt:P50876 RNF144A

Gene Names

RNF144A, KIAA0161, RNF144, UBCE7IP4

Chain

chain:1-292

Reference Genes

BioGPS Gene:9781 RNF144A

COSMIC (genes):RNF144A RNF144A

CTD Gene:9781 RNF144A

dbSNP Gene:9781 RNF144A

ENSEMBL:ENSG00000151692 RNF144A

HGNC:20457 RNF144A

KEGG:hsa:9781 RNF144A

Monarch:9781 RNF144A

NCBI Gene:9781 RNF144A

OMIM:619454 RNF144A

UCSC:P50876 RNF144A

Reference Transcript

Other Identifiers

11756828_a_at

11757347_s_at

16876777

204040_PM_at

204040_at

2468377

2468381

2468383

2468384

2468395

2468399

2468409

2468410

2468411

2468412

2468413

2468416

2468417

2468421

2468422

2468423

2468425

2468427

2468428

2468429

2468430

2468431

2468437

37695_at

8040090

9781

A_14_P201091

A_23_P131566

A_24_P37264

D79983_at

GE57305

GO:0000151

GO:0000209

GO:0002221

GO:0002376

GO:0003824

GO:0004842

GO:0005515

GO:0005737

GO:0005768

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0006511

GO:0008270

GO:0010008

GO:0016020

GO:0016567

GO:0016740

GO:0031410

GO:0031624

GO:0043226

GO:0043231

GO:0046872

GO:0061630

GO:0085020

GO:0140096

HMNXSV003039942

ILMN_1777660

ILMN_1816374

PH_hs_0028992

TC02000035.hg

g7661955_3p_at

Participates

as an output of

RNF144A polyubiquitinates PRKDC (Homo sapiens)

as a component of

RNF144A:PRKDC:Ub:UBE2L3 [cytosol] (Homo sapiens)

as an input of

RNF144A binds PRKDC and Ubiquitin:UBE2L3 (Homo sapiens)

Inferred To

CG12339 [endosome membrane] (Drosophila melanogaster)

RNF144A [endosome membrane] (Bos taurus)

RNF144A [endosome membrane] (Canis familiaris)

RNF144A [endosome membrane] (Danio rerio)

RNF144A [endosome membrane] (Dictyostelium discoideum)

RNF144A [endosome membrane] (Gallus gallus)

RNF144A [endosome membrane] (Mus musculus)

RNF144A [endosome membrane] (Sus scrofa)

RNF144A [endosome membrane] (Xenopus tropicalis)

Rnf144a [endosome membrane] (Rattus norvegicus)

Cross References

ENSEMBL

ENST00000320892, ENSP00000321330, ENSG00000151692

OpenTargets

ENSG00000151692

GeneCards

RNF144A

HPA

ENSG00000151692-RNF144A

PRO

P50876

Pharos - Targets

P50876

PDB

1WIM, 6L99

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P68036 UBE2L3	4	Ub-C86-UBE2L3 [cytosol] (R-HSA-8864201) UBE2L3 [cytosol] (R-HSA-947631) UBE2L3 [nucleoplasm] (R-HSA-8852056) Ub-C86-UBE2L3 [nucleoplasm] (R-HSA-8864226)	0.666	4
UniProt:Q07065 CKAP4	7	CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956737) p-CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956926) CKAP4 [specific granule membrane] (R-HSA-6799552) CKAP4 [plasma membrane] (R-HSA-5686306) CKAP4 [azurophil granule membrane] (R-HSA-6799559) PALM-C100-CKAP4 [plasma membrane] (R-HSA-5686280) PALM-C100-CKAP4 [lamellar body] (R-HSA-5686285)	0.589	2
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.556	3
UniProt:Q96IW7 SEC22A	3	SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111) SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562)	0.556	3
UniProt:Q6TCH4 PAQR6			0.556	3
UniProt:Q96EQ0 SGTB			0.556	3
UniProt:Q96AA3 RFT1	2	RFT1 R67C [endoplasmic reticulum membrane] (R-HSA-4570578) RFT1 [endoplasmic reticulum membrane] (R-HSA-449255)	0.556	3
UniProt:Q6N075 MFSD5			0.556	3
IntAct:EBI-22326698 CCSB ORF ID			0.556	3
UniProt:Q6ZPD8 DGAT2L6	1	DGAT2L6 [endoplasmic reticulum membrane] (R-HSA-8848588)	0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.556	3

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