Reactome | RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3

RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3

Stable Identifier

R-HSA-8938829

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, lysosomal membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The ubiquitin E3 ligase RNF152 located in the lysosomal membrane (Zhang et al. 2010) binds GDP-bound RRAGA and the E2-ubiquitin conjugate UBE2N:Ubiquitin prior to ubiquitinating RRAGA (Deng et al. 2015), RNF152, like many E3 ligases, can also autoubiquitinate (Zhang et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
21203937	RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities Wu, W, Zheng, J, Tang, H, Wu, Y, Suo, T, Zhang, S, Tang, J	Protein Cell	2010
25936802	The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation Chen, L, Li, D, Jin, J, Chen, M, Xu, Y, Wang, P, Pan, W, Deng, L, Zhao, L, Liao, L, Wang, X, Wei, J, Chu, H, Li, L, Jiang, C, Liu, M, Ge, X	Mol. Cell	2015