Reactome | K48polyUb-BCL10 [cytosol]

K48polyUb-BCL10 [cytosol]

Stable Identifier

R-HSA-8939329

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

B-cell lymphoma/leukemia 10, BCL10_HUMAN

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Literature References

PubMed ID	Title	Journal	Year
26711259	Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181 Pomerantz, JL, Mackie, dS, Chan, W, Pedersen, SM, Jattani, RP	Mol. Cell. Biol.	2016

External Reference Information

External Reference

UniProt:O95999 BCL10

Gene Names

BCL10, CIPER, CLAP

Chain

chain:1-233

Reference Genes

COSMIC (genes):BCL10 BCL10

ENSEMBL:ENSG00000142867 BCL10

HGNC:989 BCL10

UCSC:O95999 BCL10

Other Identifiers

11726703_a_at

11726704_x_at

11753497_a_at

16689060

205263_PM_at

205263_at

2420809

2420810

2420811

2420812

2420813

2420814

2420815

2420816

2420817

2420821

2420822

2420823

2420824

2420825

2420826

38871_at

74831_r_at

7917338

8915

89594_f_at

A_23_P115286

A_24_P19983

A_33_P3392447

GE79818

GO:0001772

GO:0001783

GO:0001819

GO:0001843

GO:0002020

GO:0002096

GO:0002224

GO:0002250

GO:0002376

GO:0002906

GO:0003713

GO:0005515

GO:0005634

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0005881

GO:0006355

GO:0006915

GO:0006968

GO:0009620

GO:0012501

GO:0016020

GO:0016064

GO:0019209

GO:0030674

GO:0031398

GO:0031625

GO:0031663

GO:0032094

GO:0032449

GO:0032496

GO:0032755

GO:0032757

GO:0032761

GO:0032765

GO:0032991

GO:0035591

GO:0038061

GO:0042327

GO:0042802

GO:0042981

GO:0043065

GO:0043123

GO:0043226

GO:0043280

GO:0043422

GO:0044877

GO:0045087

GO:0045121

GO:0045893

GO:0048471

GO:0050700

GO:0050852

GO:0050856

GO:0050862

GO:0050870

GO:0051059

GO:0051092

GO:0051260

GO:0060090

GO:0061760

GO:0065003

GO:0070231

GO:0071222

GO:0071260

GO:0098542

GO:0098772

GO:0140110

GO:0140296

GO:2001238

HMNXSV003050401

ILMN_1716446

PH_hs_0011415

TC01002828.hg

g4092066_3p_at

Participates

as an output of

RNF181 polyubiquinates BCL10 (Homo sapiens)

Other forms of this molecule

BCL10 [cytosol]

p-BCL10 [cytosol]

Inferred To

BCL10 [cytosol] (Bos taurus)

BCL10 [cytosol] (Canis familiaris)

BCL10 [cytosol] (Gallus gallus)

BCL10 [cytosol] (Sus scrofa)

Bcl10 [cytosol] (Mus musculus)

Bcl10 [cytosol] (Rattus norvegicus)

Modified Residues

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

ENSEMBL

ENSP00000498104, ENST00000648566

OpenTargets

ENSG00000142867

HPA

ENSG00000142867-BCL10

PRO

O95999

Pharos - Targets

O95999

GlyGen

O95999

Orphanet

BCL10

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UDY8 MALT1	1	MALT1 [cytosol] (R-HSA-202461)	0.942	24
UniProt:Q9BXL7 CARD11	5	p-S559,S644,S652-CARD11 [plasma membrane] (R-HSA-1168564) CARD11 [plasma membrane] (R-HSA-2685592) p-S559,S652-CARD11 [cytosol] (R-HSA-2685625) CARD11 [cytosol] (R-HSA-202161) p-S552-CARD11 [cytosol] (R-HSA-202438)	0.857	7
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.85	11
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.789	7
UniProt:O95999 BCL10	3	K48polyUb-BCL10 [cytosol] (R-HSA-8939329) BCL10 [cytosol] (R-HSA-202447) p-BCL10 [cytosol] (R-HSA-202488)	0.749	5
IntAct:EBI-4399559 UBIQ			0.704	5
UniProt:Q9Y2V7 COG6	2	COG6 [trans-Golgi network membrane] (R-HSA-6813872) COG6 [Golgi membrane] (R-HSA-2980958)	0.696	5
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.69	5
UniProt:Q96LW7 CAR19			0.602	4
UniProt:Q9H257 CARD9	3	CARD9 [cytosol] (R-HSA-561194) p-T231-CARD9 [plasma membrane] (R-HSA-5607623) CARD9 [plasma membrane] (R-HSA-5607662)	0.547	6
UniProt:P20749 BCL3			0.524	3
UniProt:Q05513 PRKCZ	5	pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824) PRKCZ [cytosol] (R-HSA-58218) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) p-T410-PRKCZ [cytosol] (R-HSA-437181) PRKCZ [cell junction] (R-HSA-2134483)	0.518	3
UniProt:Q66677 VCLAP			0.508	2

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