SCF(SKP2) complex binds RUNX2

Stable Identifier
R-HSA-8939688
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The E3 ubiquitin ligase complex SCF binds RUNX2 through direct interaction between SKP2 subunit of the SCF complex and RUNX2 (Thacker et al. 2016). This process is inhibited by glucose uptake in osteoblasts (Wei et al. 2015).
Literature References
PubMed ID Title Journal Year
26091038 Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation

Pessin, JE, Wei, J, Lezaki, T, Hinoi, E, Shimazu, J, Kajimura, D, Karsenty, G, Zong, H, Maurizi, A, Makinistoglu, MP, Takarada, T

Cell 2015
26778333 Skp2 inhibits osteogenesis by promoting ubiquitin-proteasome degradation of Runx2

Khan, MP, Kumar, Y, Trivedi, AK, Kanaujiya, JK, Kapoor, I, Sanyal, S, Thacker, G, Chattopadhyay, N, Lochab, S, Ahmed, S, Shukla, N

Biochim. Biophys. Acta 2016
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