Reactome | 26S proteasome degrades PolyUb-RUNX2

26S proteasome degrades PolyUb-RUNX2

Stable Identifier

R-HSA-8939801

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Polyubiquitinated RUNX2 is degraded by the proteasome. As it has not been examined whether SCF(SKP2)-mediated polyubiquitination of RUNX2 leads to translocation of PolyUb-RUNX2 to the cytosol (Thacker et al. 2016), proteasome mediated degradation is assumed to happen in the nucleus. This process is inhibited by glucose uptake in osteoblasts (Wei et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
26091038	Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation Pessin, JE, Wei, J, Lezaki, T, Hinoi, E, Shimazu, J, Kajimura, D, Karsenty, G, Zong, H, Maurizi, A, Makinistoglu, MP, Takarada, T	Cell	2015
26778333	Skp2 inhibits osteogenesis by promoting ubiquitin-proteasome degradation of Runx2 Khan, MP, Kumar, Y, Trivedi, AK, Kanaujiya, JK, Kapoor, I, Sanyal, S, Thacker, G, Chattopadhyay, N, Lochab, S, Ahmed, S, Shukla, N	Biochim. Biophys. Acta	2016