Reactome | NT5E:Zn2+ hydrolyses NMN

NT5E:Zn2+ hydrolyses NMN

Stable Identifier

R-HSA-8940074

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

beta-nicotinamide D-ribonucleotide + H2O => beta-nicotinamide D-riboside + phosphate

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Cell recruitment (pro-inflammatory response) (Homo sapiens)
        
        Purinergic signaling in leishmaniasis infection (Homo sapiens)
        
        NT5E:Zn2+ hydrolyses NMN (Homo sapiens)

General

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5'-nucleotidase (NT5E, CD73) hydrolyzes beta-nicotinamide D-ribonucleotide (NMN) to yield nicotinamide-beta-riboside (NR) and phosphate, annotated here, as well as catalyzing the hydrolysis of a variety of nucleotide monophosphates (Garavaglia et al. 2012). NT5E is a glycolipid-anchored plasma membrane enzyme (Misumi et al. 1990) that is active in dimeric form and requires one zinc ion per subunit (Zimmermann 1992).

Literature References

PubMed ID	Title	Journal	Year
1637327	5'-nucleotidase: molecular structure and functional aspects Zimmermann, H	Biochem J	1992
2129526	Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form Misumi, Y, Ogata, S, Ohkubo, K, Hirose, S, Ikehara, Y	Eur J Biochem	1990
21933152	The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism Garavaglia, S, Bruzzone, S, Cassani, C, Canella, L, Allegrone, G, Sturla, L, Mannino, E, Millo, E, De Flora, A, Rizzi, M	Biochem. J.	2012