Superoxide and nitric oxide react to peroxynitrite in the phagosome

Stable Identifier
R-HSA-8942052
Type
Reaction [transition]
Species
Homo sapiens
Compartment
phagocytic vesicle lumen
ReviewStatus
5/5
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Superoxide and nitric oxide react to peroxynitrite in the phagosome
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Inside the phagosome, nitric oxide and superoxide react at diffusion controlled rates with each other to yield peroxynitrite (Prolo C et al. 2014; Ferrer-Sueta G & Radi R 2009).
Literature References
PubMed ID Title Journal Year
24281946 Peroxynitrite, a potent macrophage-derived oxidizing cytotoxin to combat invading pathogens

Alvarez, MN, Radi, R, Prolo, C

Biofactors 2014
7762673 The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide

Squadrito, GL, Pryor, WA

Am J Physiol 1995
8396550 The reaction of no with superoxide

Huie, RE, Padmaja, S

Free Radic. Res. Commun. 1993
20194496 Peroxynitrite is the major species formed from different flux ratios of co-generated nitric oxide and superoxide: direct reaction with boronate-based fluorescent probe

Kalyanaraman, B, Zielonka, J, Sikora, A, Joseph, J

J. Biol. Chem. 2010
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Cross References
Rhea
Authored
Shamovsky, V  (2018-10-23)
Reviewed
Nüsse, O  (2018-11-07)
Warner, D  (2012-04-30)
Created
Shamovsky, V  (2016-10-07)
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