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p-Y88-CDKN1B [nucleoplasm]
Stable Identifier
R-HSA-8942808
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-Y88-p27KIP1
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Homo sapiens)
CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
CDK4,CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Homo sapiens)
CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
CDK4,CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of mitotic cell cycle (Homo sapiens)
Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P46527 CDKN1B
Gene Names
CDKN1B, KIP1
Chain
chain:1-198
Reference Genes
BioGPS Gene:1027 CDKN1B
COSMIC (genes):CDKN1B CDKN1B
CTD Gene:1027 CDKN1B
dbSNP Gene:1027 CDKN1B
ENSEMBL:ENSG00000111276 CDKN1B
HGNC:1785 CDKN1B
KEGG Gene (Homo sapiens):1027 CDKN1B
Monarch:1027 CDKN1B
NCBI Gene:1027 CDKN1B
OMIM:600778 CDKN1B
Reference Transcript
RefSeq:NM_004064.4 CDKN1B
Other Identifiers
0002100280
1027
11717091_s_at
11748603_a_at
16748477
2034_s_at
209112_at
33847_s_at
33848_r_at
3405445
3405446
3405449
3405455
3405456
52535_s_at
7954029
A_14_P102019
A_23_P204696
A_24_P81841
GE81344
GO:0000003
GO:0000079
GO:0000082
GO:0000278
GO:0001666
GO:0001890
GO:0003674
GO:0004860
GO:0004861
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005829
GO:0006464
GO:0006469
GO:0006810
GO:0006813
GO:0006950
GO:0006977
GO:0007010
GO:0007049
GO:0007050
GO:0007096
GO:0007165
GO:0007219
GO:0007507
GO:0007605
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008285
GO:0009056
GO:0009058
GO:0009749
GO:0010942
GO:0014070
GO:0016301
GO:0016310
GO:0019221
GO:0019899
GO:0019901
GO:0019903
GO:0022607
GO:0030154
GO:0030234
GO:0030308
GO:0030332
GO:0030544
GO:0031116
GO:0031410
GO:0031464
GO:0032355
GO:0032991
GO:0033673
GO:0034641
GO:0040007
GO:0042127
GO:0042326
GO:0042493
GO:0043066
GO:0043200
GO:0043226
GO:0043231
GO:0043434
GO:0044877
GO:0045732
GO:0045736
GO:0045737
GO:0045786
GO:0045787
GO:0045892
GO:0045930
GO:0046686
GO:0048102
GO:0048839
GO:0048856
GO:0050680
GO:0050877
GO:0051087
GO:0051271
GO:0060770
GO:0065003
GO:0071236
GO:0071285
GO:0071407
GO:0071850
GO:0140014
GO:1902746
GO:1902806
GO:1904030
GO:1904706
GO:1905179
HMNXSV003015053
HMNXSV003043906
ILMN_1722811
ILMN_2196347
PH_hs_0012886
TC12000178.hg
TC12002253.hg
g12805034_3p_at
Participates
as a component of
CDK4,CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-T187-CDKN1B [nucleoplasm]
CDKN1B [nucleoplasm]
p-Y88-CDKN1B [cytosol]
CDKN1B [cytosol]
p-T157-CDKN1B [cytosol]
p-S10 CDKN1B [nucleoplasm]
p-S10 CDKN1B [cytosol]
Inferred To
phospho-CDKN1B [nucleoplasm]
(Bos taurus)
phospho-CDKN1B [nucleoplasm]
(Sus scrofa)
phospho-Cdkn1b [nucleoplasm]
(Mus musculus)
phospho-Cdkn1b [nucleoplasm]
(Rattus norvegicus)
phospho-p-Y88-CDKN1B [nucleoplasm]
(Xenopus tropicalis)
phospho-cdkn1bb [nucleoplasm]
(Danio rerio)
phospho-dap [nucleoplasm]
(Drosophila melanogaster)
Modified Residues
Name
O4'-phospho-L-tyrosine at 88
Coordinate
88
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_004055.1
OpenTargets
ENSG00000111276
HPA
ENSG00000111276-CDKN1B
GeneCards
P46527
Ensembl
ENST00000228872
,
ENSG00000111276
,
ENSP00000228872
PRO
P46527
Pharos - Targets
P46527
Orphanet
18426
PDB
7B5M
,
6ATH
,
6P8F
,
2AST
,
1H27
,
1JSU
,
6P8E
,
7B5R
,
6P8G
,
5UQ3
,
7B5L
Interactors (38)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.97
25
UniProt:P20248 CCNA2
3
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [cytosol]
(R-HSA-157444)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.963
17
UniProt:P11802 CDK4
3
CDK4 [cytosol]
(R-HSA-68330)
CDK4 [nucleoplasm]
(R-HSA-113843)
p-T172-CDK4 [nucleoplasm]
(R-HSA-113830)
0.92
9
UniProt:Q00535 CDK5
4
CDK5 [nucleoplasm]
(R-HSA-8863586)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
CDK5 [cytosol]
(R-HSA-180064)
0.907
9
UniProt:P24385 CCND1
4
CCND1 [nucleoplasm]
(R-HSA-113832)
CCND1 [cytosol]
(R-HSA-68328)
p-T286-CCND1 [nucleoplasm]
(R-HSA-75811)
p-T286-CCND1 [cytosol]
(R-HSA-75813)
0.813
5
UniProt:P24864 CCNE1
3
Unfolded CCNE1 [cytosol]
(R-HSA-6813836)
CCNE1 [cytosol]
(R-HSA-157443)
CCNE1 [nucleoplasm]
(R-HSA-68363)
0.806
8
UniProt:P06493 CDK1
10
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [cytosol]
(R-HSA-170075)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
0.802
5
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.799
6
UniProt:P30279 CCND2
2
CCND2 [cytosol]
(R-HSA-68340)
CCND2 [nucleoplasm]
(R-HSA-113827)
0.766
6
UniProt:Q13309 SKP2
3
SKP2 [nucleoplasm]
(R-HSA-975554)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [cytosol]
(R-HSA-975495)
0.75
4
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.743
4
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.724
5
UniProt:P78396 CCNA1
3
PolyUb-CCNA1 [nucleoplasm]
(R-HSA-6783068)
CCNA1 [cytosol]
(R-HSA-157446)
CCNA1 [nucleoplasm]
(R-HSA-68891)
0.72
6
UniProt:O15131 KPNA5
2
KPNA5 [nucleoplasm]
(R-HSA-1176068)
KPNA5 [cytosol]
(R-HSA-1176062)
0.718
6
UniProt:O96020 CCNE2
3
Unfolded CCNE2 [cytosol]
(R-HSA-6813844)
CCNE2 [cytosol]
(R-HSA-157452)
CCNE2 [nucleoplasm]
(R-HSA-68367)
0.646
3
UniProt:P31749 AKT1
13
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.63
3
UniProt:Q62120 Jak2
11
Jak2 [cytosol]
(R-MMU-210620)
phospho-Jak2 [cytosol]
(R-MMU-873799)
Jak2 [cytosol]
(R-MMU-205743)
phospho-Jak2 [cytosol]
(R-MMU-2586516)
p-12Y-Jak2 [cytosol]
(R-MMU-2586515)
p-Y1007-Jak2 [cytosol]
(R-MMU-997296)
Jak2 [endosome lumen]
(R-MMU-2002372)
phospho-Jak2 [cytosol]
(R-MMU-997248)
phospho-Jak2 [cytosol]
(R-MMU-210621)
p-Jak2 [cytosol]
(R-MMU-8950633)
phospho-Jak2 [cytosol]
(R-MMU-9005327)
0.626
7
UniProt:Q13616 CUL1
3
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [nucleoplasm]
(R-HSA-187551)
CUL1 [cytosol]
(R-HSA-174230)
0.609
2
UniProt:Q92905 COPS5
2
COPS5 [nucleoplasm]
(R-HSA-5697019)
COPS5 [cytosol]
(R-HSA-416963)
0.602
3
UniProt:P16949 STMN1
1
STMN1 [cytosol]
(R-HSA-9612290)
0.589
3
UniProt:O00505 KPNA3
2
KPNA3 [nucleoplasm]
(R-HSA-1176061)
KPNA3 [cytosol]
(R-HSA-1176070)
0.576
4
UniProt:P14635 CCNB1
4
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
CCNB1 [cytosol]
(R-HSA-157451)
0.564
2
UniProt:Q5MJ70 SPDYA
0.556
3
UniProt:Q5JR59-3 MTUS2
0.556
3
UniProt:Q8N9N5-2 BANP
0.556
3
UniProt:Q9NVV9 THAP1
0.556
3
UniProt:P30281 CCND3
2
CCND3 [nucleoplasm]
(R-HSA-113835)
CCND3 [cytosol]
(R-HSA-68333)
0.547
2
UniProt:P07948 LYN
7
MyrG2-PalmC3-LYN [lysosomal membrane]
(R-HSA-9707903)
MyrG2-PalmC3-LYN [endocytic vesicle membrane]
(R-HSA-9705728)
LYN [plasma membrane]
(R-HSA-197943)
p-Y397-LYN [cytosol]
(R-HSA-8942608)
LYN [cytosol]
(R-HSA-354251)
MyrG2-PalmC3-LYN [plasma membrane]
(R-HSA-9606875)
p-Y396-LYN [plasma membrane]
(R-HSA-2454229)
0.544
2
UniProt:Q15418 RPS6KA1
7
RPS6KA1 [nucleoplasm]
(R-HSA-199860)
p-4S,T359,T573-RPS6KA1 [nucleoplasm]
(R-HSA-199829)
RPS6KA1 [cytosol]
(R-HSA-444256)
p-T359,S363,T573-RPS6KA1 [cytosol]
(R-HSA-9619957)
p-S221,T459,S363,S380,T573,T732-RPS6KA1 [cytosol]
(R-HSA-9619871)
p-T359,S363,S380.T573,T372-RPS6KA1 [cytosol]
(R-HSA-9619993)
p-S221,T359,S363,S380,T573,T732-RPS6KA1 [nucleoplasm]
(R-HSA-444292)
0.544
2
UniProt:P61586 RHOA
6
RHOA [endoplasmic reticulum membrane]
(R-HSA-5672082)
RHOA [secretory granule membrane]
(R-HSA-6804980)
RHOA [ficolin-1-rich granule membrane]
(R-HSA-6804971)
RHOA [cytosol]
(R-HSA-194866)
RHOA [cell junction]
(R-HSA-2134503)
RHOA [plasma membrane]
(R-HSA-194510)
0.544
3
UniProt:Q00526 CDK3
0.527
2
UniProt:P33993 MCM7
1
MCM7 [nucleoplasm]
(R-HSA-68555)
0.527
2
UniProt:P63208 SKP1
2
SKP1 [nucleoplasm]
(R-HSA-187538)
SKP1 [cytosol]
(R-HSA-174150)
0.524
2
UniProt:P11440 Cdk1
10
phospho-Cdk1 [nucleoplasm]
(R-MMU-170066)
phospho-Cdk1 [nucleoplasm]
(R-MMU-170074)
phospho-Cdk1 [cytosol]
(R-MMU-157415)
phospho-Cdk1 [cytosol]
(R-MMU-170071)
Cdk1 [cytosol]
(R-MMU-170075)
phospho-Cdk1 [nucleoplasm]
(R-MMU-170078)
phospho-Cdk1 [nucleoplasm]
(R-MMU-170045)
phospho-Cdk1 [cytosol]
(R-MMU-170064)
Cdk1 [nucleoplasm]
(R-MMU-1362302)
Cdk1 [endoplasmic reticulum membrane]
(R-MMU-264424)
0.499
2
UniProt:Q9UQR0-1 SCML2
0.499
2
UniProt:P70168
5
Kpnb1 [specific granule lumen]
(R-MMU-6799646)
Kpnb1 [extracellular region]
(R-MMU-6806306)
Kpnb1 [ficolin-1-rich granule lumen]
(R-MMU-6800978)
Kpnb1 [nucleoplasm]
(R-MMU-180714)
Kpnb1 [cytosol]
(R-MMU-180733)
0.499
4
UniProt:Q00534 CDK6
3
CDK6 [cytosol]
(R-HSA-68336)
CDK6 [nucleoplasm]
(R-HSA-141283)
p-T177-CDK6 [nucleoplasm]
(R-HSA-69628)
0.483
2
UniProt:P09936 UCHL1
1
UCHL1 [cytosol]
(R-HSA-5660679)
0.463
2
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