Reactome | SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N

SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N

Stable Identifier

R-HSA-8943007

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N

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At stalled replication forks, the E3 ubiquitin ligase SHPRH interacts with PCNA monoubiquitinated at lysine-164 (monoUb-K164-PCNA), the RAD18:UBE2B complex (RAD18:RAD6 complex), and the Ub:UBE2N:UBE2V2 complex (UBC13:MMS2 complex with ubiquitin conjugated to UBC13) (Unk et al. 2006, Motegi et al. 2006, Motegi et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18719106	Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks Roest, HP, Ding, H, Motegi, A, Myung, K, Markowitz, SD, Wu, X, Liaw, HJ, Lee, KY, Moinova, H, Hoeijmakers, JH, Maas, A	Proc. Natl. Acad. Sci. U.S.A.	2008
17108083	Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen Haracska, L, Hurwitz, J, Blastyák, A, Bermudez, V, Prakash, L, Fatyol, K, Hajdu, I, Unk, I, Szakál, B, Prakash, S	Proc. Natl. Acad. Sci. U.S.A.	2006
17130289	Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination Motegi, A, Myung, K, Markowitz, SD, Sood, R, Liu, PP, Moinova, H	J. Cell Biol.	2006