Reactome | MECOM [nucleoplasm]

MECOM [nucleoplasm]

Stable Identifier

R-HSA-8943897

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

MDS1 and EVI1 complex locus protein EVI1, EVI1_HUMAN, PRDM3, KMT8E

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q03112 MECOM

Gene Names

MECOM, EVI1, MDS1, PRDM3

Chain

chain:1-1230

Reference Genes

BioGPS Gene:2122 Q031129

COSMIC (genes):MECOM MECOM

CTD Gene:2122 Q031129

dbSNP Gene:2122 MECOM

ENSEMBL:ENSG00000085276 MECOM

HGNC:3498 Q031129

KEGG:hsa:2122 Q031129

Monarch:2122 Q031129

NCBI Gene:2122 Q031129

OMIM:165215 Q031129

OMIM:600049 Q031129

UCSC:Q03112 Q031129

Reference Transcript

Participates

as an output of

Expression of MECOM (EVI1) in the nephric duct (Homo sapiens)

as an input of

MECOM (EVI1) binds the PTEN gene promoter (Homo sapiens)

as a component of

Other forms of this molecule

MECOM [cytosol]

Inferred To

MECOM [nucleoplasm] (Bos taurus)

MECOM [nucleoplasm] (Canis familiaris)

MECOM [nucleoplasm] (Gallus gallus)

MECOM [nucleoplasm] (Sus scrofa)

che-1 [nucleoplasm] (Caenorhabditis elegans)

Mecom [nucleoplasm] (Mus musculus)

Mecom [nucleoplasm] (Rattus norvegicus)

prz1 [nucleoplasm] (Schizosaccharomyces pombe)

ham [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001157471.1, XP_005247277.1, XP_005247278.1, NP_001353398.1, XP_005247276.1, NP_001157472.1, NP_001353395.1, XP_016861363.1, XP_016861364.1, NP_001353401.1, NP_005232.2, NP_001353400.1, NP_001353399.1, XP_005247272.1, XP_005247280.1, XP_047303643.1, NP_001192123.1, XP_047303642.1, NP_004982.2, XP_016861365.1, NP_001098547.3, NP_001098548.2

OpenTargets

ENSG00000085276

ENSEMBL

ENST00000468789, ENST00000628990, ENSG00000085276, ENSP00000486104, ENSP00000498411, ENST00000264674, ENSP00000419770, ENST00000651503, ENST00000494292, ENSP00000264674, ENSP00000417899, ENST00000464456, ENSP00000419995

HPA

ENSG00000085276-MECOM

GeneCards

MECOM

PRO

Q03112

Pharos - Targets

Q03112

Orphanet

MECOM

GlyGen

Q03112

PDB

6BW3

HMDB Protein

HMDBP14555

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.645	4
UniProt:P56546 Ctbp2	1	Ctbp2 [nucleoplasm] (R-MMU-5333990)	0.635	3
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.615	3
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.593	5
UniProt:Q5R372-2 RABGAP1L			0.57	3
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.499	4
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.488	2

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