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MECOM [nucleoplasm]
Stable Identifier
R-HSA-8943897
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
MDS1 and EVI1 complex locus protein EVI1, EVI1_HUMAN, PRDM3, KMT8E
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Kidney development (Homo sapiens)
Formation of the nephric duct (Homo sapiens)
Expression of MECOM (EVI1) in the nephric duct (Homo sapiens)
MECOM [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
MECOM (EVI1) binds the PTEN gene promoter (Homo sapiens)
MECOM [nucleoplasm] (Homo sapiens)
MECOM:PTEN gene [nucleoplasm] (Homo sapiens)
MECOM [nucleoplasm] (Homo sapiens)
MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
MECOM [nucleoplasm] (Homo sapiens)
MECOM:PTEN gene [nucleoplasm] (Homo sapiens)
MECOM [nucleoplasm] (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
MECOM [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
MECOM [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q03112 MECOM
Gene Names
MECOM, EVI1, MDS1, PRDM3
Chain
chain:1-1230
Reference Genes
COSMIC (genes):MECOM Q031129
dbSNP Gene:2122 Q031129
ENSEMBL:ENSG00000085276 MECOM
Participates
as an output of
Expression of MECOM (EVI1) in the nephric duct (Homo sapiens)
as an input of
MECOM (EVI1) binds the PTEN gene promoter (Homo sapiens)
as a component of
MECOM:PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
MECOM [cytosol]
Inferred To
MECOM [nucleoplasm]
(Canis familiaris)
MECOM [nucleoplasm]
(Gallus gallus)
MECOM [nucleoplasm]
(Sus scrofa)
sfc2 [nucleoplasm]
(Schizosaccharomyces pombe)
Homologues of MECOM [nucleoplasm]
(Schizosaccharomyces pombe)
prz1 [nucleoplasm]
(Schizosaccharomyces pombe)
egl-43 [nucleoplasm]
(Caenorhabditis elegans)
ham [nucleoplasm]
(Drosophila melanogaster)
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.645
4
UniProt:P56546 Ctbp2
1
CTBP2 [nucleoplasm]
(R-MMU-5333990)
0.635
3
UniProt:Q13363 CTBP1
3
CTBP1 [nucleoplasm]
(R-HSA-212372)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
0.615
3
UniProt:Q9UBK9 UXT
1
UXT [nucleoplasm]
(R-HSA-9007484)
0.593
5
UniProt:Q5R372-2 RABGAP1L
0.57
3
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.499
4
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.488
2
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