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MECOM [nucleoplasm]
Stable Identifier
R-HSA-8943897
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
MDS1 and EVI1 complex locus protein EVI1, EVI1_HUMAN, PRDM3, KMT8E
Locations in the PathwayBrowser for interactor UniProt:P56546%20Ctbp2
Expand all
Developmental Biology (Homo sapiens)
Kidney development (Homo sapiens)
Formation of the nephric duct (Homo sapiens)
Expression of MECOM (EVI1) in the nephric duct (Homo sapiens)
MECOM [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
MECOM (EVI1) binds the PTEN gene promoter (Homo sapiens)
MECOM [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q03112 MECOM
Gene Names
MECOM, EVI1, MDS1, PRDM3
Chain
chain:1-1230
Reference Genes
BioGPS Gene:2122 MECOM
COSMIC (genes):MECOM MECOM
CTD Gene:2122 MECOM
dbSNP Gene:2122 MECOM
ENSEMBL:ENSG00000085276 MECOM
ENSEMBL_homo_sapiens_GENE:ENSG00000085276.19 MECOM
HGNC:3498 MECOM
KEGG Gene (Homo sapiens):2122 MECOM
Monarch:2122 MECOM
NCBI Gene:2122 MECOM
OMIM:165215 MECOM
OMIM:600049 MECOM
UCSC:Q03112 MECOM
Reference Transcript
RefSeq:XM_005247221.2 MECOM
RefSeq:NM_001105077.3 MECOM
RefSeq:XM_017005876.1 MECOM
RefSeq:NM_001205194.1 MECOM
RefSeq:NM_001164000.1 MECOM
RefSeq:XM_005247219.2 MECOM
RefSeq:XM_005247220.2 MECOM
RefSeq:XM_005247215.3 MECOM
RefSeq:XM_017005875.1 MECOM
RefSeq:XM_017005874.1 MECOM
RefSeq:NM_001163999.1 MECOM
RefSeq:NM_005241.3 MECOM
RefSeq:NM_001105078.3 MECOM
RefSeq:NM_004991.3 MECOM
RefSeq:XM_005247223.2 MECOM
Other Identifiers
11727645_a_at
11734506_a_at
11734507_s_at
16961331
1881_at
1882_g_at
2122
221884_PM_at
221884_at
226420_PM_at
226420_at
2704442
2704443
2704444
2704448
2704449
2704451
2704453
2704456
2704457
2704460
2704461
2704463
2704464
2704468
2704469
2704472
2704473
2704474
2704482
2704483
2704489
2704490
2704491
2704492
2704493
2704531
2704532
2704533
2704599
2704600
46205_at
59145_at
8091972
8091991
A_23_P212688
A_23_P317324
A_24_P15154
A_24_P153490
A_24_P320103
A_33_P3888629
GE59162
GE629408
GE88841
GO:0000118
GO:0000978
GO:0001228
GO:0003677
GO:0003700
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0006915
GO:0008168
GO:0012501
GO:0016607
GO:0016740
GO:0023052
GO:0030154
GO:0032259
GO:0042803
GO:0043069
GO:0043226
GO:0045892
GO:0045893
GO:0045944
GO:0046329
GO:0046872
GO:0046974
GO:0048856
GO:0051726
GO:0070828
GO:0071425
GO:0140096
GO:0140110
GO:0140938
GO:0140947
GO:0140948
HMNXSV003002560
HMNXSV003054030
Hs.234773.0.S1_3p_at
Hs.234773.0.S2_3p_at
ILMN_1803367
PH_hs_0035989
Participates
as an output of
Expression of MECOM (EVI1) in the nephric duct (Homo sapiens)
as an input of
MECOM (EVI1) binds the PTEN gene promoter (Homo sapiens)
as a component of
MECOM:PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
MECOM [cytosol]
Inferred To
MECOM [nucleoplasm]
(Canis familiaris)
MECOM [nucleoplasm]
(Gallus gallus)
MECOM [nucleoplasm]
(Sus scrofa)
sfc2 [nucleoplasm]
(Schizosaccharomyces pombe)
Homologues of MECOM [nucleoplasm]
(Schizosaccharomyces pombe)
prz1 [nucleoplasm]
(Schizosaccharomyces pombe)
egl-43 [nucleoplasm]
(Caenorhabditis elegans)
ham [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
XP_016861364.1
,
XP_005247277.1
,
NP_005232.2
,
XP_005247278.1
,
NP_001157471.1
,
XP_016861365.1
,
NP_001157472.1
,
NP_001098548.2
,
NP_004982.2
,
XP_005247272.1
,
NP_001192123.1
,
NP_001098547.3
,
XP_005247280.1
,
XP_016861363.1
,
XP_005247276.1
OpenTargets
ENSG00000085276
GeneCards
Q03112
HPA
ENSG00000085276-MECOM
Ensembl
ENSG00000085276
,
ENSP00000486104
,
ENST00000494292
,
ENST00000264674
,
ENSP00000419995
,
ENSP00000264674
,
ENSP00000417899
,
ENST00000651503
,
ENST00000464456
,
ENST00000468789
,
ENST00000628990
,
ENSP00000419770
,
ENSP00000498411
PRO
Q03112
Pharos - Targets
Q03112
Orphanet
17464
HMDB Protein
HMDBP14555
PDB
6BW3
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.645
4
UniProt:P56546 Ctbp2
0.635
3
UniProt:Q9UBK9 UXT
1
UXT [nucleoplasm]
(R-HSA-9007484)
0.593
5
UniProt:Q5R372-2 RABGAP1L
0.57
3
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.499
4
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.488
2
UniProt:Q13363 CTBP1
3
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
CTBP1 [nucleoplasm]
(R-HSA-212372)
0.483
2
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