TCF/LEF binds WNT promoters

Stable Identifier
Reaction [binding]
Homo sapiens
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TCF7 (TCF1), LEF1, TCF7L1 (TCF3) and TCF7L2 (TCF4) are HMG box-containing DNA-binding proteins that recognize WNT-responsive elements (WREs) in the promoters of WNT target genes. The WRE consensus sequence is CCTTTGWW, where W represents either T or A (reviewed in Brantjes et al, 2002). In the absence of a WNT signal, promoter-bound TCF/LEF is bound by one of four Groucho homologues, TLE1, 2, 3 or 4 (Levanon et al, 1998; Brantjes et al, 2001; Daniels and Weis, 2005). Groucho/TLE proteins are co-repressors for a variety of DNA-binding transcription factors and mediate repression at least in part through their interaction with histone deacetylases such as RPD3/HDAC1 (Arce et al, 2009; Brantjes et al, 2001; Chen et al, 1999; reviewed in Chen and Courey, 2000).

Literature References
PubMed ID Title Journal Year
15768032 Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation

Daniels, DL, Weis, WI

Nat Struct Mol Biol 2005
19460168 Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression

Arce, L, Pate, KT, Waterman, ML

BMC Cancer 2009
11266540 All Tcf HMG box transcription factors interact with Groucho-related co-repressors

Brantjes, H, Roose, J, van De Wetering, M, Clevers, HC

Nucleic Acids Res. 2001
9751710 Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

Levanon, D, Goldstein, RE, Bernstein, Y, Tang, H, Goldenberg, D, Stifani, S, Paroush, Z, Groner, Y

Proc. Natl. Acad. Sci. U.S.A. 1998
11934263 TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling

Brantjes, H, Barker, N, van Es, J, Clevers, HC

Biol. Chem. 2002
10485845 A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development

Chen, G, Fernandez, J, Mische, S, Courey, AJ

Genes Dev. 1999
10831834 Groucho/TLE family proteins and transcriptional repression

Chen, G, Courey, AJ

Gene 2000
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