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CDKN1C [nucleoplasm]
Stable Identifier
R-HSA-8948130
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, p57Kip2, Kip2
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Homo sapiens)
CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
Cyclin D:CDK4,CDK6:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1C [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1C [nucleoplasm] (Homo sapiens)
Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1C [nucleoplasm] (Homo sapiens)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1C [nucleoplasm] (Homo sapiens)
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1C [nucleoplasm] (Homo sapiens)
RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1C [nucleoplasm] (Homo sapiens)
Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Homo sapiens)
CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
Cyclin D:CDK4,CDK6:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1C [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of mitotic cell cycle (Homo sapiens)
Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Homo sapiens)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
CDKN1C [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49918 CDKN1C
Gene Names
CDKN1C, KIP2
Chain
chain:1-316
Reference Genes
BioGPS Gene:1028 CDKN1C
COSMIC (genes):CDKN1C CDKN1C
CTD Gene:1028 CDKN1C
dbSNP Gene:1028 CDKN1C
ENSEMBL:ENSG00000129757 CDKN1C
ENSEMBL_homo_sapiens_GENE:ENSG00000129757.15 CDKN1C
HGNC:1786 CDKN1C
KEGG Gene (Homo sapiens):1028 CDKN1C
Monarch:1028 CDKN1C
NCBI Gene:1028 CDKN1C
OMIM:600856 CDKN1C
UCSC:P49918 CDKN1C
Reference Transcript
RefSeq:NM_001122630.1 CDKN1C
RefSeq:XM_017017088.1 CDKN1C
RefSeq:NM_000076.2 CDKN1C
RefSeq:NM_001122631.1 CDKN1C
Other Identifiers
1028
11729118_a_at
11763717_a_at
11763718_x_at
16734475
1787_at
213182_PM_x_at
213182_x_at
213348_PM_at
213348_at
216894_PM_x_at
216894_x_at
219534_PM_x_at
219534_x_at
3359434
3359435
3359436
3359437
3359438
3359439
3359440
3359441
3359442
3359443
3359444
3359445
38673_s_at
39545_at
7945767
GO:0000122
GO:0000278
GO:0001501
GO:0001822
GO:0001890
GO:0004860
GO:0004861
GO:0005515
GO:0005634
GO:0005737
GO:0006325
GO:0006351
GO:0006355
GO:0007049
GO:0007096
GO:0022414
GO:0023052
GO:0030099
GO:0030154
GO:0030325
GO:0030511
GO:0033673
GO:0035264
GO:0036211
GO:0042326
GO:0042551
GO:0043010
GO:0043226
GO:0044877
GO:0045892
GO:0045893
GO:0045930
GO:0048856
GO:0050680
GO:0051171
GO:0051726
GO:0055123
GO:0060065
GO:0060255
GO:0060669
GO:0071514
GO:0080090
GO:0098772
GO:0140014
GO:0140678
GO:1902746
GO:1904030
HMNXSV003055621
Hs.106070.1.S1_3p_at
Hs.106070.3.S1_3p_a_at
ILMN_1718565
PH_hs_0005906
TC11001284.hg
TC11003009.hg
U22398_at
Participates
as a candidate of
CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-Y91-CDKN1C [cytosol]
CDKN1C [cytosol]
Inferred To
CDKN1C [nucleoplasm]
(Bos taurus)
CDKN1C [nucleoplasm]
(Canis familiaris)
CDKN1C [nucleoplasm]
(Sus scrofa)
Cdkn1c [nucleoplasm]
(Mus musculus)
Cdkn1c [nucleoplasm]
(Rattus norvegicus)
dap [nucleoplasm]
(Drosophila melanogaster)
cdknx [nucleoplasm]
(Xenopus tropicalis)
cdkn1c [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
XP_016872577.1
,
NP_000067.1
,
NP_001116102.1
,
NP_001116103.1
OpenTargets
ENSG00000129757
HPA
ENSG00000129757-CDKN1C
GeneCards
P49918
Ensembl
ENST00000430149
,
ENST00000414822
,
ENST00000440480
,
ENSG00000129757
,
ENSP00000411552
,
ENSP00000411257
,
ENSP00000413720
PRO
P49918
Pharos - Targets
P49918
Orphanet
15425
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P33993 MCM7
1
MCM7 [nucleoplasm]
(R-HSA-68555)
0.527
2
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.527
2
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