FUNDC1 is phosphorylated by ULK1 at Ser17

Stable Identifier
R-HSA-8948146
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
ReviewStatus
5/5
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FUNDC1 is phosphorylated by ULK1 at Ser17
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At mitochondria, ULK1 interacts with FUNDC1, phosphorylating it at serine 17, which enhances FUNDC1 binding to LC3. FUNDC1 regulates ULK1 recruitment to damaged mitochondria; FUNDC1 phosphorylation by ULK1 is crucial for mitophagy.

Literature References
PubMed ID Title Journal Year
24671035 ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

Feng, D, Hu, Z, Tian, W, Zhang, L, Sui, S, Wu, W, Xue, P, Li, W, Zhang, X, Liu, L, Zhao, B, Zhou, C, Huang, L, Li, L, Zhu, Y, Chen, G, Zhang, X

EMBO Rep. 2014
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of ULK1 [mitochondrial outer membrane]

Physical Entity
ULK1 [mitochondrial outer membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
FUNDC1 is phosphorylated by ULK1 at Ser17 (Bos taurus)
FUNDC1 is phosphorylated by ULK1 at Ser17 (Caenorhabditis elegans)
FUNDC1 is phosphorylated by ULK1 at Ser17 (Canis familiaris)
FUNDC1 is phosphorylated by ULK1 at Ser17 (Danio rerio)
FUNDC1 is phosphorylated by ULK1 at Ser17 (Dictyostelium discoideum)
FUNDC1 is phosphorylated by ULK1 at Ser17 (Drosophila melanogaster)
FUNDC1 is phosphorylated by ULK1 at Ser17 (Gallus gallus)
FUNDC1 is phosphorylated by ULK1 at Ser17 (Mus musculus)
FUNDC1 is phosphorylated by ULK1 at Ser17 (Rattus norvegicus)
FUNDC1 is phosphorylated by ULK1 at Ser17 (Saccharomyces cerevisiae)
FUNDC1 is phosphorylated by ULK1 at Ser17 (Schizosaccharomyces pombe)
FUNDC1 is phosphorylated by ULK1 at Ser17 (Sus scrofa)
FUNDC1 is phosphorylated by ULK1 at Ser17 (Xenopus tropicalis)
Authored
Gillespie, ME  (2016-11-02)
Reviewed
Feng, D  (2017-01-26)
Created
Gillespie, ME  (2016-11-11)
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