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PGR [cytosol]
Stable Identifier
R-HSA-8948964
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PGR-1, Progesterone receptor isoform 1
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Homo sapiens)
PGR:P4 [cytosol] (Homo sapiens)
PGR [cytosol] (Homo sapiens)
P4 bind PGR (in the HSP90 chaperone complex) (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Homo sapiens)
PGR [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol] (Homo sapiens)
PGR:P4 [cytosol] (Homo sapiens)
PGR [cytosol] (Homo sapiens)
PGR binds PGR agonists (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Homo sapiens)
PGR [cytosol] (Homo sapiens)
PGR:PGR agonists [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Homo sapiens)
PGR [cytosol] (Homo sapiens)
PGR binds PGR antagonists (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Homo sapiens)
PGR [cytosol] (Homo sapiens)
PGR:PGR antagonists [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Homo sapiens)
PGR [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P06401 PGR
Gene Names
PGR, NR3C3
Chain
chain:1-933
Reference Genes
BioGPS Gene:5241 PGR
COSMIC (genes):PGR PGR
CTD Gene:5241 PGR
dbSNP Gene:5241 PGR
ENSEMBL:ENSG00000082175 PGR
ENSEMBL_homo_sapiens_GENE:ENSG00000082175.16 PGR
HGNC:8910 PGR
KEGG Gene (Homo sapiens):5241 PGR
Monarch:5241 PGR
NCBI Gene:5241 PGR
OMIM:607311 PGR
UCSC:P06401 PGR
Reference Transcript
RefSeq:NM_000926.4 PGR
RefSeq:NM_001202474.3 PGR
RefSeq:NM_001271161.2 PGR
RefSeq:NM_001271162.1 PGR
Other Identifiers
11726167_a_at
11726168_at
11750900_a_at
11750901_x_at
160021_r_at
16743577
208305_PM_at
208305_at
228554_PM_at
228554_at
3388369
3388370
3388371
3388372
3388373
3388374
3388375
3388376
3388377
3388378
3388379
3388380
3388382
3388383
3388387
3388393
3388407
3388408
3388410
3388411
3388412
3388413
3388414
3388415
426_at
44598_at
5241
7951165
81847_at
83526_at
A_23_P138938
A_32_P49199
GE59760
GE630055
GE900767
GO:0000785
GO:0000978
GO:0000981
GO:0001223
GO:0001228
GO:0001542
GO:0002070
GO:0002071
GO:0003676
GO:0003677
GO:0003700
GO:0003707
GO:0004879
GO:0004930
GO:0005102
GO:0005496
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005739
GO:0005741
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006357
GO:0007165
GO:0007186
GO:0007267
GO:0008270
GO:0008289
GO:0010628
GO:0010629
GO:0016020
GO:0019899
GO:0022414
GO:0023052
GO:0030154
GO:0030518
GO:0030879
GO:0034056
GO:0038001
GO:0042802
GO:0043226
GO:0043401
GO:0043565
GO:0045944
GO:0046872
GO:0048286
GO:0048856
GO:0050678
GO:0050847
GO:0051117
GO:0060089
GO:0060748
GO:0140110
GO:1990837
HMNXSV003001822
HMNXSV003041440
Hs.32405.0.S1_3p_at
ILMN_1811014
PH_hs_0000369
PH_hs_0002738
TC11002220.hg
TC11003308.hg
TC11003309.hg
X51730_at
g4505766_3p_at
Participates
as a component of
PGR:P4 [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] (Homo sapiens)
Other forms of this molecule
monoSUMO1-K7,K388,K531-PGR [nucleoplasm]
PGR [nucleoplasm]
Inferred To
Ghost homologue of PGR [cytosol]
(Plasmodium falciparum)
PGR [cytosol]
(Bos taurus)
PGR [cytosol]
(Canis familiaris)
PGR [cytosol]
(Gallus gallus)
PGR [cytosol]
(Mus musculus)
PGR [cytosol]
(Rattus norvegicus)
PGR [cytosol]
(Sus scrofa)
pgr [cytosol]
(Danio rerio)
knrl [cytosol]
(Drosophila melanogaster)
Homologues of PGR [cytosol]
(Canis familiaris)
Homologues of PGR [cytosol]
(Drosophila melanogaster)
ERR [cytosol]
(Drosophila melanogaster)
eg [cytosol]
(Drosophila melanogaster)
kni [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_000917.3
,
NP_001258091.1
,
NP_001189403.1
,
NP_001258090.1
ZINC - World Drugs
PRGR_HUMAN
Guide to Pharmacology - Targets
627
OpenTargets
ENSG00000082175
ZINC - FDA approved
PRGR_HUMAN
ZINC - Substances
PRGR_HUMAN
ZINC target
P06401
ZINC - Biogenic
PRGR_HUMAN
PRO
P06401
PDB
4APU
,
1A28
,
1SQN
,
1SR7
,
4OAR
,
2OVH
,
3HQ5
,
2OVM
,
4A2J
,
1E3K
,
3KBA
,
3ZRB
,
3ZR7
,
1ZUC
,
2C7A
,
5CC0
,
2W8Y
,
3D90
,
3ZRA
,
3G8O
ZINC - Investigational
PRGR_HUMAN
ZINC - Metabolites
PRGR_HUMAN
GeneCards
P06401
HPA
ENSG00000082175-PGR
Ensembl
ENST00000534013
,
ENSG00000082175
,
ENSP00000263463
,
ENST00000325455
,
ENSP00000436561
,
ENSP00000325120
,
ENST00000263463
Pharos - Targets
P06401
ZINC - Predictions - Purchasable
PRGR_HUMAN
HMDB Protein
HMDBP01681
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.774
20
UniProt:Q9H467 CUED2
0.66
9
UniProt:P06401 PGR
3
monoSUMO1-K7,K388,K531-PGR [nucleoplasm]
(R-HSA-4341032)
PGR [cytosol]
(R-HSA-8948964)
PGR [nucleoplasm]
(R-HSA-3008952)
0.623
2
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.623
3
IntAct:EBI-2119323 CCND1
0.527
5
UniProt:P08047 SP1
1
SP1 [nucleoplasm]
(R-HSA-1592223)
0.462
2
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