Reactome | PGR [cytosol]

PGR [cytosol]

Stable Identifier

R-HSA-8948964

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PGR-1, Progesterone receptor isoform 1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P06401 PGR

Gene Names

PGR, NR3C3

Chain

chain:1-933

Reference Genes

BioGPS Gene:5241 PGR

COSMIC (genes):PGR PGR

CTD Gene:5241 PGR

dbSNP Gene:5241 PGR

ENSEMBL:ENSG00000082175 PGR

HGNC:8910 PGR

KEGG:hsa:5241 PGR

Monarch:5241 PGR

NCBI Gene:5241 PGR

OMIM:607311 PGR

UCSC:P06401 PGR

Reference Transcript

Participates

as a component of

Other forms of this molecule

PGR [nucleoplasm]

monoSUMO1-K7,K388,K531-PGR [nucleoplasm]

Inferred To

Ghost homologue of PGR [cytosol] (Plasmodium falciparum)

PGR [cytosol] (Bos taurus)

PGR [cytosol] (Canis familiaris)

PGR [cytosol] (Gallus gallus)

PGR [cytosol] (Sus scrofa)

pgr [cytosol] (Danio rerio)

pgr [cytosol] (Xenopus tropicalis)

knrl [cytosol] (Drosophila melanogaster)

Homologues of PGR [cytosol] (Drosophila melanogaster)

ERR [cytosol] (Drosophila melanogaster)

Pgr [cytosol] (Mus musculus)

Pgr [cytosol] (Rattus norvegicus)

eg [cytosol] (Drosophila melanogaster)

kni [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001189403.1, NP_000917.3, NP_001258090.1, NP_001258091.1

ZINC - World Drugs

PRGR_HUMAN

Guide to Pharmacology - Targets

627

OpenTargets

ENSG00000082175

ENSEMBL

ENST00000534013, ENSP00000436561, ENST00000263463, ENSG00000082175, ENSP00000325120, ENST00000325455, ENSP00000263463

ZINC - FDA approved

PRGR_HUMAN

ZINC - Substances

PRGR_HUMAN

ZINC - Biogenic

PRGR_HUMAN

ZINC target

P06401

PRO

P06401

GlyGen

P06401

PDB

3D90, 1SR7, 4A2J, 1A28, 1ZUC, 3ZRA, 2OVH, 4OAR, 5CC0, 2W8Y, 2OVM, 3G8O, 4APU, 3ZR7, 1E3K, 3HQ5, 3KBA, 3ZRB, 2C7A, 1SQN

ZINC - Investigational

PRGR_HUMAN

ZINC - Metabolites

PRGR_HUMAN

HPA

ENSG00000082175-PGR

GeneCards

PGR

Pharos - Targets

P06401

ZINC - Predictions - Purchasable

PRGR_HUMAN

HMDB Protein

HMDBP01681

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.774	20
UniProt:Q9H467 CUED2			0.66	9
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-STAT3 [cytosol] (R-HSA-8982823) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-S727-STAT3 [cytosol] (R-HSA-198705) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.623	3
UniProt:P06401 PGR	3	PGR [nucleoplasm] (R-HSA-3008952) PGR [cytosol] (R-HSA-8948964) monoSUMO1-K7,K388,K531-PGR [nucleoplasm] (R-HSA-4341032)	0.623	2
IntAct:EBI-2119323 CCND1			0.527	5
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.462	2

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