Reactome | MCUB [mitochondrial inner membrane]

MCUB [mitochondrial inner membrane]

Stable Identifier

R-HSA-8949153

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

fullName evidence="6"Calcium uniporter regulatory subunit MCUb, mitochondrial, MCUB_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q15047 SETDB1

Expand all

External Reference Information

External Reference

UniProt:Q9NWR8 MCUB

Gene Names

MCUB, CCDC109B

Chain

transit peptide:1-35, chain:36-336

Reference Genes

BioGPS Gene:55013 MCUB

COSMIC (genes):MCUB MCUB

CTD Gene:55013 MCUB

dbSNP Gene:55013 MCUB

ENSEMBL:ENSG00000005059 MCUB

ENSEMBL_homo_sapiens_GENE:ENSG00000005059.16 MCUB

HGNC:26076 MCUB

KEGG Gene (Homo sapiens):55013 MCUB

Monarch:55013 MCUB

NCBI Gene:55013 MCUB

OMIM:620702 MCUB

UCSC:Q9NWR8 MCUB

Reference Transcript

RefSeq:NM_017918.4 MCUB

Other Identifiers

11755137_a_at

11758793_at

16969686

218802_PM_at

218802_at

2739162

2739177

2739178

2739179

2739181

2739191

2739192

2739193

2739194

2739196

2739197

2739198

2739199

2739200

2739201

55013

61857_at

63853_at

64277_i_at

64278_f_at

64279_f_at

8096808

A_14_P124825

A_14_P133198

A_23_P255376

GE82249

GO:0005634

GO:0005654

GO:0005739

GO:0005743

GO:0006811

GO:0006816

GO:0006851

GO:0016020

GO:0019855

GO:0034704

GO:0036444

GO:0043226

GO:0043231

GO:0051560

GO:0055065

GO:0055085

GO:0098772

GO:1990246

HMNXSV003018535

ILMN_1801766

PH_hs_0012788

TC04000564.hg

g8923601_3p_at

Participates

as an input of

SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex (Homo sapiens)

as a component of

MCU complex [mitochondrial inner membrane] (Homo sapiens)

Inferred To

MCU [mitochondrial inner membrane] (Drosophila melanogaster)

Mcub [mitochondrial inner membrane] (Mus musculus)

Mcub [mitochondrial inner membrane] (Rattus norvegicus)

mcu-1 [mitochondrial inner membrane] (Caenorhabditis elegans)

MCUB [mitochondrial inner membrane] (Bos taurus)

MCUB [mitochondrial inner membrane] (Canis familiaris)

MCUB [mitochondrial inner membrane] (Dictyostelium discoideum)

MCUB [mitochondrial inner membrane] (Gallus gallus)

MCUB [mitochondrial inner membrane] (Sus scrofa)

mcub [mitochondrial inner membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_060388.2

OpenTargets

ENSG00000005059

GeneCards

Q9NWR8

HPA

ENSG00000005059-MCUB

Ensembl

ENST00000394650, ENSP00000378145, ENSG00000005059

PRO

Q9NWR8

Pharos - Targets

Q9NWR8

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CS3 FAF2	3	FAF2 [cytosol] (R-HSA-6781921) FAF2 [extracellular region] (R-HSA-6806183) FAF2 [azurophil granule lumen] (R-HSA-6799138)	0.527	2
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	2
UniProt:Q12797 ASPH	2	ASPH [endoplasmic reticulum lumen] (R-HSA-9631383) ASPH [endoplasmic reticulum membrane] (R-HSA-5490331)	0.527	3
UniProt:P52815 MRPL12	2	MRPL12 [mitochondrial matrix] (R-HSA-9839674) MRPL12 [mitochondrial inner membrane] (R-HSA-5368256)	0.527	2
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.499	3

Cite Us!