Reactome | CHCHD6 (MIC25) [mitochondrial inner membrane]

CHCHD6 (MIC25) [mitochondrial inner membrane]

Stable Identifier

R-HSA-8949568

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

CHCHD6, MICOS complex subunit MIC25, MIC25_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O75431 MTX2

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External Reference Information

External Reference

UniProt:Q9BRQ6 CHCHD6

Gene Names

CHCHD6, CHCM1, MIC25

Chain

initiator methionine:1, chain:2-235

Reference Genes

BioGPS Gene:84303 CHCHD6

COSMIC (genes):CHCHD6 CHCHD6

CTD Gene:84303 CHCHD6

dbSNP Gene:84303 CHCHD6

ENSEMBL:ENSG00000159685 CHCHD6

HGNC:28184 CHCHD6

KEGG:hsa:84303 CHCHD6

Monarch:84303 CHCHD6

NCBI Gene:84303 CHCHD6

OMIM:615634 CHCHD6

UCSC:Q9BRQ6 CHCHD6

Reference Transcript

Other Identifiers

11721850_a_at

11721851_x_at

16945034

224462_PM_s_at

224462_s_at

2640508

2640509

2640512

2640513

2640515

2640530

2640541

2640543

2640551

2640554

2640555

2640556

2640557

2640558

2640560

2640564

2640565

2640566

2640567

2640569

2640570

2640571

2640572

8082305

84303

91662_at

A_14_P125652

A_23_P91870

A_33_P3235975

GE86952

GO:0001401

GO:0005515

GO:0005739

GO:0005743

GO:0005829

GO:0006974

GO:0007007

GO:0016020

GO:0042407

GO:0044284

GO:0061617

GO:0140275

HMNXSV003022972

ILMN_1785161

PH_hs_0004788

PH_hs_0034449

g13543969_3p_s_at

Participates

as a component of

MICOS [mitochondrial inner membrane] (Homo sapiens)

as an input of

Formation of MIB complex containing the MICOS complex causes curvature of mitochondrial inner membrane (Homo sapiens)

Cross References

RefSeq

NP_001307539.1, NP_115719.1

ENSEMBL

ENST00000290913, ENSG00000159685, ENSP00000290913

OpenTargets

ENSG00000159685

GeneCards

CHCHD6

HPA

ENSG00000159685-CHCHD6

PRO

Q9BRQ6

Pharos - Targets

Q9BRQ6

GlyGen

Q9BRQ6

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75431 MTX2	1	MTX2 [mitochondrial outer membrane] (R-HSA-1252142)	0.725	5
UniProt:Q86VW1 SLC22A16	1	SLC22A16 [plasma membrane] (R-HSA-561104)	0.643	3
UniProt:Q9NX63 CHCHD3	3	CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874907) 4xHC-CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874910) CHCHD3 (MIC19) [mitochondrial inner membrane] (R-HSA-8949583)	0.564	2
UniProt:Q9Y512 SAMM50	1	SAMM50 [mitochondrial outer membrane] (R-HSA-1252178)	0.556	3
UniProt:Q5TGI0 FAXC			0.527	3
UniProt:P43361 MAGA8			0.527	2
UniProt:Q9UPV9 TRAK1	3	TRAK1(1-325)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802554) TRAK1(1-325)-RAF1(279-648) fusion [cytosol] (R-HSA-6802474) TRAK1 [cytosol] (R-HSA-5578870)	0.527	3
UniProt:P43005 SLC1A1	4	SLC1A1 [plasma membrane] (R-HSA-210414) SLC1A1 R445W [plasma membrane] (R-HSA-5625045) SLC1A1 84kb_del [plasma membrane] (R-HSA-5625040) SLC1A1 I395del [plasma membrane] (R-HSA-5625023)	0.527	2
UniProt:Q9BZW8 CD244	1	CD244 [plasma membrane] (R-HSA-197846)	0.527	2
UniProt:Q6UXV4 APOOL	3	APOOL (MIC27) [mitochondrial inner membrane] (R-HSA-8949612) APOOL [extracellular region] (R-HSA-8862979) APOOL [platelet alpha granule lumen] (R-HSA-8863003)	0.527	4
UniProt:Q9NY25 CLEC5A	3	CLEC5A [tertiary granule membrane] (R-HSA-6801019) CLEC5A [specific granule membrane] (R-HSA-6799520) CLEC5A [plasma membrane] (R-HSA-210028)	0.527	2
UniProt:Q9H9B4 SFXN1			0.483	2
UniProt:Q8WYQ3 CHCHD10	2	4xHC-CHCHD10 [mitochondrial intermembrane space] (R-HSA-8874883) CHCHD10 [mitochondrial intermembrane space] (R-HSA-8874860)	0.471	2

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