Reactome | IMMT (MIC60) [mitochondrial inner membrane]

IMMT (MIC60) [mitochondrial inner membrane]

Stable Identifier

R-HSA-8949569

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

IMMT, MICOS complex subunit MIC60, MIC60_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q16891 IMMT

Gene Names

IMMT, HMP, MIC60, MINOS2, PIG4, PIG52

Chain

transit peptide:1-33, chain:34-758

Reference Genes

BioGPS Gene:10989 IMMT

COSMIC (genes):IMMT IMMT

CTD Gene:10989 IMMT

dbSNP Gene:10989 IMMT

ENSEMBL:ENSG00000132305 IMMT

ENSEMBL:ENSG00000132305.22 IMMT

HGNC:6047 IMMT

KEGG Gene (Homo sapiens):10989 IMMT

Monarch:10989 IMMT

NCBI Gene:10989 IMMT

OMIM:600378 IMMT

UCSC:Q16891 IMMT

Reference Transcript

Other Identifiers

10989

11715552_a_at

11715553_s_at

11747392_x_at

11750128_s_at

11752417_a_at

11752789_s_at

16899846

200955_PM_at

200955_at

2562688

2562689

2562690

2562691

2562692

2562694

2562697

2562700

2562704

2562706

2562711

2562713

2562716

2562719

2562720

2562725

2562726

37659_at

3934637

8053533

85005_g_at

A_23_P39844

A_24_P351304

A_33_P3314468

GE57777

GO:0001401

GO:0003723

GO:0005515

GO:0005739

GO:0005743

GO:0005758

GO:0007005

GO:0007007

GO:0016020

GO:0042407

GO:0043226

GO:0044284

GO:0051560

GO:0055065

GO:0061024

GO:0061617

GO:0070050

GO:0110165

GO:0140275

HMNXSV003006928

ILMN_1782579

L42572_at

PH_hs_0029552

TC02002052.hg

g5803114_3p_at

Participates

as a component of

MICOS [mitochondrial inner membrane] (Homo sapiens)

as an input of

Formation of MIB complex containing the MICOS complex causes curvature of mitochondrial inner membrane (Homo sapiens)

Cross References

RefSeq

NP_006830.2, XP_005264170.1, XP_016858683.1, NP_001093639.1, NP_001093640.1

OpenTargets

ENSG00000132305

GeneCards

Q16891

HPA

ENSG00000132305-IMMT

Ensembl

ENSP00000387262, ENSG00000132305, ENST00000410111, ENSP00000407788, ENST00000449247, ENST00000442664, ENSP00000396899

PRO

Q16891

Pharos - Targets

Q16891

Orphanet

24620

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	7
UniProt:Q8WYQ3 CHCHD10	2	4xHC-CHCHD10 [mitochondrial intermembrane space] (R-HSA-8874883) CHCHD10 [mitochondrial intermembrane space] (R-HSA-8874860)	0.602	4
UniProt:Q5VU43 MYOME			0.573	2
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:O60925 PFDN1	1	PFDN1 [cytosol] (R-HSA-379541)	0.553	2
UniProt:Q9NRI5 DISC1			0.553	3
UniProt:Q9H9J2 MRPL44	1	MRPL44 [mitochondrial inner membrane] (R-HSA-5368245)	0.553	2
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.553	2
UniProt:O75431 MTX2	1	MTX2 [mitochondrial outer membrane] (R-HSA-1252142)	0.527	2
UniProt:Q9NX63 CHCHD3	3	CHCHD3 (MIC19) [mitochondrial inner membrane] (R-HSA-8949583) CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874907) 4xHC-CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874910)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.508	2
UniProt:Q8TAG9 EXOC6	2	EXOC6 [plasma membrane] (R-HSA-265041) EXOC6 [cytosol] (R-HSA-5623384)	0.508	2
UniProt:P08559 PDHA1	1	PDHA1 [mitochondrial matrix] (R-HSA-69966)	0.499	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.463	4

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