Reactome | F1Fo ATP synthase dimerizes

F1Fo ATP synthase dimerizes

Stable Identifier

R-HSA-8949580

Type

Reaction [binding]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

F1Fo ATP synthase binds F1Fo ATP synthase

ReviewStatus

5/5

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At the inner mitochondrial membrane, an F1Fo ATP synthase complex binds another F1Fo ATP synthase complex to form a dimer that causes curvature of the inner mitochondrial membrane at internal regions of cristae (Habersetzer et al. 2013, inferred from bovine homologs in Strauss et al. 2008, Davies et al. 2011, Davies et al. 2012, inferred from yeast homologs in Arnold et al. 1998, Couoh-Cardel et al. 2010). The dimers are observed in rows along the highly curved apices of cristae (inferred from bovine homologs in Davies et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
18323778	Dimer ribbons of ATP synthase shape the inner mitochondrial membrane Schröder, RR, Kühlbrandt, W, Hofhaus, G, Strauss, M	EMBO J.	2008
24098383	Human F1F0 ATP synthase, mitochondrial ultrastructure and OXPHOS impairment: a (super-)complex matter? Paumard, P, Salin, B, Priault, M, Rossignol, R, Habersetzer, J, Larrieu, I, Brèthes, D	PLoS ONE	2013
20833715	Structure of dimeric F1F0-ATP synthase García-Trejo, JJ, Wilkens, S, Uribe-Carvajal, S, Couoh-Cardel, SJ	J. Biol. Chem.	2010
25285856	Visualization of ATP synthase dimers in mitochondria by electron cryo-tomography Daum, B, Brandt, T, Mühleip, AW, Gold, VA, Kühlbrandt, W, Blum, TB, Davies, KM, Mills, DJ	J Vis Exp	2014
22864911	Structure of the yeast F1Fo-ATP synthase dimer and its role in shaping the mitochondrial cristae Wittig, I, Anselmi, C, Kühlbrandt, W, Davies, KM, Faraldo-Gómez, JD	Proc. Natl. Acad. Sci. U.S.A.	2012
17121862	ATP6 homoplasmic mutations inhibit and destabilize the human F1F0-ATP synthase without preventing enzyme assembly and oligomerization García, JJ, Cortés-Hernández, P, Vázquez-Memije, ME	J. Biol. Chem.	2007
21836051	Macromolecular organization of ATP synthase and complex I in whole mitochondria Osiewacz, HD, Daum, B, Kief, JH, Kühlbrandt, W, Rycovska, A, Davies, KM, Zickermann, V, Strauss, M	Proc. Natl. Acad. Sci. U.S.A.	2011