Reactome | CHCHD3 (MIC19) [mitochondrial inner membrane]

CHCHD3 (MIC19) [mitochondrial inner membrane]

Stable Identifier

R-HSA-8949583

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

CHCHD3, MICOS complex subunit MIC19, MIC19_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NX63 CHCHD3

Gene Names

CHCHD3, MIC19, MINOS3

Chain

initiator methionine:, chain:2-227

Reference Genes

BioGPS Gene:54927 CHCHD3

COSMIC (genes):CHCHD3 CHCHD3

CTD Gene:54927 CHCHD3

dbSNP Gene:54927 CHCHD3

ENSEMBL:ENSG00000106554 CHCHD3

HGNC:21906 CHCHD3

KEGG:hsa:54927 CHCHD3

Monarch:54927 CHCHD3

NCBI Gene:54927 CHCHD3

OMIM:613748 CHCHD3

UCSC:Q9NX63 CHCHD3

Reference Transcript

Other Identifiers

11726318_s_at

11753342_x_at

11753592_x_at

11757083_s_at

11760429_at

1676_s_at

17063047

17063066

200689_3p_x_at

200689_PM_x_at

200689_x_at

211345_3p_x_at

211345_PM_x_at

211345_x_at

211927_3p_x_at

211927_PM_x_at

211927_x_at

217972_PM_at

217972_at

2402993

2402994

2402995

3073634

3073643

3073650

3073663

3073675

3073698

3073699

3073700

3073701

3073703

3073704

3073713

3073717

3073722

3073723

3073748

3073749

3073750

3073751

3073752

3073753

3073754

3073755

3073756

3073757

3073758

3073760

3234481

3375806

3375807

3375809

3375811

3375815

3375816

3375820

3375822

3375824

3375826

3988067

3988082

3988084

46233_at

54927

8143028

8143035

A_23_P13344

A_23_P251927

A_24_P287198

A_24_P467358

GE55487

GE61363

GO:0001401

GO:0005515

GO:0005634

GO:0005737

GO:0005739

GO:0005743

GO:0007005

GO:0007007

GO:0008053

GO:0016020

GO:0019902

GO:0042407

GO:0043226

GO:0044284

GO:0060090

GO:0061024

GO:0061617

GO:0070062

GO:0140275

HMNXSV003038176

HMNXSV003051962

HMNXSV003053972

Hs.2186.3.S1_3p_a_at

Hs.2186.3.S1_3p_x_at

ILMN_1673026

ILMN_1680437

M55409_s_at

TC11003185.hg

TC11003483.hg

g4503480_3p_a_at

g7770136_3p_a_at

g8923389_3p_at

Participates

as a component of

MICOS [mitochondrial inner membrane] (Homo sapiens)

as an input of

Formation of MIB complex containing the MICOS complex causes curvature of mitochondrial inner membrane (Homo sapiens)

Other forms of this molecule

CHCHD3 [mitochondrial intermembrane space]

4xHC-CHCHD3 [mitochondrial intermembrane space]

Cross References

OpenTargets

ENSG00000106554

ENSEMBL

ENSP00000262570, ENST00000262570

HPA

ENSG00000106554-CHCHD3

PRO

Q9NX63

Pharos - Targets

Q9NX63

GlyGen

Q9NX63

Interactors (53)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y512 SAMM50	1	SAMM50 [mitochondrial outer membrane] (R-HSA-1252178)	0.782	7
UniProt:Q9NW38 FANCL	2	FANCL [nucleoplasm] (R-HSA-419520) FANCL [cytosol] (R-HSA-420789)	0.718	6
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.718	6
UniProt:Q16891 IMMT	1	IMMT (MIC60) [mitochondrial inner membrane] (R-HSA-8949569)	0.643	3
UniProt:O75431 MTX2	1	MTX2 [mitochondrial outer membrane] (R-HSA-1252142)	0.643	4
UniProt:Q9BRQ6 CHCHD6	1	CHCHD6 (MIC25) [mitochondrial inner membrane] (R-HSA-8949568)	0.564	2
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.564	2
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P61970 NTF2			0.556	3
UniProt:Q96KN7 RPGR1			0.556	3
UniProt:P62140 PPP1CB	4	PPP1CB [cytosol] (R-HSA-163405) PPP1CB P49R [cytosol] (R-HSA-9660547) PPP1CB A56P [cytosol] (R-HSA-9660543) PPP1CB [nucleoplasm] (R-HSA-62003)	0.556	3
UniProt:Q96QF0 RAB3IP	1	RAB3IP [cytosol] (R-HSA-5617610)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
IntAct:EBI-10171584 80125			0.556	3
UniProt:P25800 LMO1	1	LMO1 [nucleoplasm] (R-HSA-8956514)	0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q8NA61 CBY2			0.556	3
UniProt:Q15047-2 SETDB1			0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:Q9Y2D8 ADIP			0.556	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.556	3
UniProt:Q8TAP4-4 LMO3			0.556	3
UniProt:Q49AR9 Q49AR9			0.556	3
UniProt:Q8NEA9 GMCL2			0.556	3
IntAct:EBI-22314709 CCSB ORF ID			0.556	3
UniProt:A8MQ03 CRTP1			0.556	6
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:Q9H6L4 ARMC7			0.556	3
UniProt:Q9P209 CEP72	1	CEP72 [cytosol] (R-HSA-380321)	0.556	3
UniProt:Q9H0I2 ENKD1			0.556	3
UniProt:Q5VU43 MYOME			0.556	3
UniProt:Q5JVL4 EFHC1			0.556	3
UniProt:Q96R06 SPAG5			0.556	3
UniProt:Q13137 CACO2			0.556	3
UniProt:Q53TS8 CTSRT			0.556	3
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.544	2
UniProt:Q9NVH1 DNAJC11	1	DNAJC11 [mitochondrial outer membrane] (R-HSA-8949572)	0.527	2
UniProt:O96008 TOMM40	3	TOMM40 [mitochondrial intermembrane space] (R-HSA-1267971) TOMM40 [cytosol] (R-HSA-1267992) TOMM40 [mitochondrial outer membrane] (R-HSA-1252082)	0.527	2
UniProt:Q6UXV4 APOOL	3	APOOL (MIC27) [mitochondrial inner membrane] (R-HSA-8949612) APOOL [extracellular region] (R-HSA-8862979) APOOL [platelet alpha granule lumen] (R-HSA-8863003)	0.527	4
UniProt:Q15834 CC85B			0.508	2
UniProt:P61006 RAB8A	6	RAB8A [Golgi membrane] (R-HSA-2562535) RAB8A [cytosol] (R-HSA-5623399) GGC-RAB8A [cytosol] (R-HSA-8874063) GGC-RAB8A [trans-Golgi network membrane] (R-HSA-8876082) RAB8A [recycling endosome membrane] (R-HSA-8854145) GGC-RAB8A [cytoplasmic vesicle membrane] (R-HSA-1445093)	0.508	2
UniProt:P0DTD1-PRO_0000449629 REP			0.488	2
UniProt:Q8N6Y0 USBP1			0.488	2
UniProt:P14079 TAX			0.488	2
UniProt:Q15388 TOMM20	6	PolyUb-TOMM20 [mitochondrial outer membrane] (R-HSA-6783144) TOMM20 [mitochondrial outer membrane] (R-HSA-1252091) Ub-TOMM20 [mitochondrial outer membrane] (R-HSA-9834976) K48polyUb-TOMM20 [mitochondrial outer membrane] (R-HSA-9843324) K63polyUb-TOMM20 [mitochondrial outer membrane] (R-HSA-9843313) p-S65-Ub:TOMM20 [mitochondrial outer membrane] (R-HSA-9834948)	0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	6

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