Reactome | APOOL (MIC27) [mitochondrial inner membrane]

APOOL (MIC27) [mitochondrial inner membrane]

Stable Identifier

R-HSA-8949612

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

APOOL, MICOS complex subunit MIC27, MIC27_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q16891 IMMT

Expand all

External Reference Information

External Reference

UniProt:Q6UXV4 APOOL

Gene Names

APOOL, CXorf33, FAM121A, MIC27, UNQ8193/PRO23204

Chain

transit peptide:1-27, chain:28-268

Reference Genes

BioGPS Gene:139322 APOOL

COSMIC (genes):APOOL APOOL

CTD Gene:139322 APOOL

dbSNP Gene:139322 APOOL

ENSEMBL:ENSG00000155008 APOOL

ENSEMBL_homo_sapiens_GENE:ENSG00000155008.16 APOOL

HGNC:24009 APOOL

KEGG Gene (Homo sapiens):139322 APOOL

Monarch:139322 APOOL

NCBI Gene:139322 APOOL

OMIM:300955 APOOL

UCSC:Q6UXV4 APOOL

Reference Transcript

RefSeq:NM_198450.5 APOOL

Other Identifiers

11731149_a_at

11756372_a_at

139322

17105143

213282_PM_at

213282_at

213289_PM_at

213289_at

222269_PM_at

222269_at

235433_PM_at

235433_at

2833945

2833946

35257_at

3983106

3983110

3983112

3983113

3983114

3983115

3983117

3983120

3983124

3983125

3983126

3983127

3983128

3983129

3983130

3983132

51626_at

62224_at

8168580

A_23_P136986

GO:0001401

GO:0005515

GO:0005576

GO:0005739

GO:0005743

GO:0007005

GO:0007007

GO:0016020

GO:0031093

GO:0031410

GO:0042407

GO:0043226

GO:0044284

GO:0061024

GO:0061617

GO:0140275

HMNXSV003038563

HMNXSV003053538

Hs.153992.0.A1_3p_at

Hs.17947.0.A1_3p_at

Hs.5181.1.A1_3p_at

Hs.5181.1.A2_3p_at

ILMN_1777483

TC0X000439.hg

Participates

as a component of

MICOS [mitochondrial inner membrane] (Homo sapiens)

as an input of

Formation of MIB complex containing the MICOS complex causes curvature of mitochondrial inner membrane (Homo sapiens)

Other forms of this molecule

APOOL [extracellular region]

APOOL [platelet alpha granule lumen]

Cross References

RefSeq

NP_940852.3

OpenTargets

ENSG00000155008

GeneCards

Q6UXV4

HPA

ENSG00000155008-APOOL

Ensembl

ENST00000373173, ENSP00000362268, ENSG00000155008

PRO

Q6UXV4

Pharos - Targets

Q6UXV4

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y512 SAMM50	1	SAMM50 [mitochondrial outer membrane] (R-HSA-1252178)	0.527	3
UniProt:P43005 SLC1A1	4	SLC1A1 I395del [plasma membrane] (R-HSA-5625023) SLC1A1 84kb_del [plasma membrane] (R-HSA-5625040) SLC1A1 R445W [plasma membrane] (R-HSA-5625045) SLC1A1 [plasma membrane] (R-HSA-210414)	0.527	2
UniProt:O75431 MTX2	1	MTX2 [mitochondrial outer membrane] (R-HSA-1252142)	0.527	4
UniProt:Q9NX63 CHCHD3	3	CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874907) 4xHC-CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874910) CHCHD3 (MIC19) [mitochondrial inner membrane] (R-HSA-8949583)	0.527	4
UniProt:Q9BRQ6 CHCHD6	1	CHCHD6 (MIC25) [mitochondrial inner membrane] (R-HSA-8949568)	0.527	4
UniProt:Q16891 IMMT	1	IMMT (MIC60) [mitochondrial inner membrane] (R-HSA-8949569)	0.527	4
UniProt:P46059 SLC15A1	1	SLC15A1 [plasma membrane] (R-HSA-428022)	0.527	2
UniProt:O95831 AIFM1			0.483	3