NCLX catalyzes the exchange of 3-4 sodium ions from the intermembrane space for 1 calcium ion from the mitochondrial matrix (Palty et al. 2010, De Marchi et al. 2014). As a result, NCLX causes an efflux of calcium from the mitochondrial matrix and thereby attenuates calcium regulation of enzymatic activity within the mitochondrial matrix.
Caporale, T, Khananshvili, D, Silverman, WF, Herrmann, S, Nolte, C, Fishman, D, Sensi, SL, Sekler, I, Palty, R, Parnis, J, Shoshan-Barmatz, V, Hershfinkel, M
De Marchi, U, Castelbou, C, Sekler, I, Santo-Domingo, J, Wiederkehr, A, Demaurex, N
calcium:sodium antiporter activity of SLC8B1 [mitochondrial inner membrane]
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