NCLX catalyzes the exchange of 3-4 sodium ions from the intermembrane space for 1 calcium ion from the mitochondrial matrix (Palty et al. 2010, De Marchi et al. 2014). As a result, NCLX causes an efflux of calcium from the mitochondrial matrix and thereby attenuates calcium regulation of enzymatic activity within the mitochondrial matrix.
De Marchi, U, Santo-Domingo, J, Castelbou, C, Sekler, I, Wiederkehr, A, Demaurex, N
Palty, R, Silverman, WF, Hershfinkel, M, Caporale, T, Sensi, SL, Parnis, J, Nolte, C, Fishman, D, Shoshan-Barmatz, V, Herrmann, S, Khananshvili, D, Sekler, I
calcium:sodium antiporter activity of SLC8B1 [mitochondrial inner membrane]
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