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IL12RB1 binds TYK2
Stable Identifier
R-HSA-8950057
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
Synonyms
Interleukin-12 receptor subunit beta 1 binds Non-receptor tyrosine-protein kinase TYK2
ReviewStatus
5/5
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
IL12RB1 binds TYK2 (Homo sapiens)
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The intracellular domain of human Interleukin-12 receptor subunit beta-1 (IL12RB1) but not the intracellular domain of Interleukin-12 receptor subunit beta-2 (IL12RB2) interacts directly with Non-receptor tyrosine-protein kinase (TYK2) (Zou et al. 1997)
Inferred from mouse:
TYK2 associates with IL12RB1. In the absence of TYK2, IL12RB1 can associate with Tyrosine-protein kinase JAK1 (JAK1) (Floss et al. 2016).
Participants
Input
IL12RB1 [plasma membrane]
(Homo sapiens)
TYK2 [cytosol]
(Homo sapiens)
Output
IL12RB1:TYK2 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Interleukin-12 signaling (Homo sapiens)
Inferred From
Il12rb1 binds Tyk2 (Mus musculus)
Authored
Duenas, C (2016-12-02)
Reviewed
van de Vosse, E (2017-05-12)
Created
Duenas, C (2016-12-02)
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