Reactome | IL12B binds IL23A

IL12B binds IL23A

Stable Identifier

R-HSA-8950183

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Interleukin-12 subunit beta binds Interleukin-23 subunit alpha forming Interleukin-23, Interleukin-12B binds Interleukin-23A forming Interleukin-23, Interleukin-12B binds Interleukin-23A

ReviewStatus

5/5

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Interleukin 23 subunit alpha (IL23A, IL23-p19) and Interleukin 12 subunit beta (IL12B, IL-12p40) bind to form the Interleukin-23 (IL23) heterodimeric complex (IL23A:IL12B). When 293T cells were transfected with IL23A only a small amount of protein could be immunoprecipitated from the supernatant, while protein was readily detected in cellular lysates, indicating inefficient secretion. Co expression of IL23A with IL12B enhanced secretion of IL23 (Oppmann et al. 2000). Moreover there is a disulfide bridge within IL12A which is necessary fro IL12B-induced secretion. Protein disulfide isomerases enable the formation of these bridges (Reitberger et al. 2017).

Literature References

PubMed ID	Title	Journal	Year
11114383	Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 Lesley, R, Bazan, JF, Liu, M, de Waal-Malefyt, R, Yu, N, Wagner, J, Churakova, T, Vega, F, Zurawski, S, Gorman, D, Liu, Y, Hannum, C, Abrams, JS, Vaisberg, E, Oppmann, B, Singh, K, Moore, KW, Blom, B, Kastelein, RA, Hunte, B, Wang, J, Xu, Y, Timans, JC, Zonin, F, Rennick, D	Immunity	2000