Reactome | EBI3:CANX binds IL27

EBI3:CANX binds IL27

Stable Identifier

R-HSA-8950342

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Interleukin-27 subunit alpha binds Interleukin-27 subunit beta forming Interleukin-27

ReviewStatus

5/5

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Interleukin 27 subunit alpha (IL27, IL-27p28) binds Interleukin 27 subunit beta (EBI3) forming the Interleukin 27 heterodimeric complex (IL27:EBI3). When expressed alone, human EBI3 is associated with the endoplasmic reticulum (ER) resident molecular chaperone calnexin (CANX) and is retained in the ER (Devergne et al 1996). Co expression of IL27 and EBI3 enables formation of IL27:EBI3, allowing secretion (Pflanz et al. 2002).

This is a Black Box event because there is not reported which reaction occurs first: the association of IL27 to EBI3:CANX and later the Interleukin 27 heterodimeric protein formation or first the dissociation of EBI3 from CANX and later formation of the Interleukin 27 heterodimeric protein formation. Since the EBI3 is retained in the endoplasmic reticulum as a complex with CANX (Devergne et al. 1996), and the co expression of IL27 and EBI3 enable the formation of the Interleukin 27 heterodimeric complex formation, allowing secretion of this protein (Pflanz et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
12121660	IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells Vaisberg, E, Gorman, DM, Timans, JC, Gilbert, J, Mattson, JD, Hibbert, L, Travis, M, Rennick, D, To, W, Kastelein, RA, Kanzler, H, Zurawski, S, Cheung, J, Rosales, R, Pflanz, S, Wagner, JL, Blumenschein, WM, Bazan, JF, de Waal Malefyt, R, Churakova, T, McClanahan, TK	Immunity	2002