Reactome | IL12A:IL12B translocates from late endosome lumen to extracellular region

IL12A:IL12B translocates from late endosome lumen to extracellular region

Stable Identifier

R-HSA-8950347

Type

Reaction [transition]

Species

Homo sapiens

Compartment

late endosome lumen, extracellular region

Synonyms

Interleukin-12 translocates to the extracellular space, IL12A:IL12B complex is translocated to the extracellular space, Interleukin-12A:Interleukin12-B complex is translocated to the extracellular space

ReviewStatus

5/5

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IL12A:IL12B translocates from late endosome lumen to extracellular region

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Vesicle-associated membrane protein 7 (VAMP7) plays a dual role in Interleukin-12 heterodimeric protein secretion. In individual Dendritic cells, its basic function is as a positive regulator, regulating the optimal exocytosis of biologically active Interleukin-12 heterodimer produced by inflammatory stimuli. The second essential role of VAMP7 is as a negative regulator, controling non-redundantly synaptic secretion of the cytokine during interaction with a cognate T cell, i.e., at the immune synapse. Multivesicular bodies are regulated by VAMP7 and consequently Interleukin-12 heterodimer secretion is regulated by this VAMP7 (Chiaruttini et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
26972013	The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells De Nardi, F, Galli, T, Benvenuti, F, Larghi, P, Müller, S, Piperno, GM, Jouve, M, Chiaruttini, G, Valitutti, S, Peden, AA, Baj, G	Cell Rep	2016