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Go!
p-STAT1 [cytosol]
Stable Identifier
R-HSA-8950418
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser for interactor UniProt:P11277 SPTB
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-35 Signalling (Homo sapiens)
p-STAT1 dissociates from IL6ST:IL6ST (Homo sapiens)
p-STAT1 [cytosol] (Homo sapiens)
p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Homo sapiens)
p-STAT1 [cytosol] (Homo sapiens)
Interleukin-20 family signaling (Homo sapiens)
p-STAT1 dimerizes (Homo sapiens)
p-STAT1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42224 STAT1
Gene Names
STAT1
Chain
initiator methionine:, chain:2-750
Reference Genes
BioGPS Gene:6772 STAT1
COSMIC (genes):STAT1 STAT1
CTD Gene:6772 STAT1
dbSNP Gene:6772 STAT1
ENSEMBL:ENSG00000115415 STAT1
ENSEMBL_homo_sapiens_GENE:ENSG00000115415.21 STAT1
HGNC:11362 STAT1
KEGG Gene (Homo sapiens):6772 STAT1
Monarch:6772 STAT1
NCBI Gene:6772 STAT1
OMIM:600555 STAT1
UCSC:P42224 STAT1
Reference Transcript
RefSeq:NM_007315.3 STAT1
RefSeq:NM_139266.2 STAT1
RefSeq:XM_006712718.1 STAT1
Other Identifiers
11726689_a_at
11726690_a_at
11743353_s_at
16906534
200887_PM_s_at
200887_s_at
209969_PM_s_at
209969_s_at
2592269
2592271
2592272
2592273
2592274
2592275
2592276
2592279
2592281
2592282
2592283
2592284
2592286
2592289
2592292
2592294
2592296
2592298
2592299
2592300
2592303
2592304
2592306
2592309
2592310
2592317
2592318
2592319
2592320
2592321
2592324
2592325
2592326
2592327
2592329
2592330
2592331
2592332
32859_at
32860_g_at
33338_at
33339_g_at
6772
8057744
AFFX-HUMISGF3A/M97935_3_at
AFFX-HUMISGF3A/M97935_5_at
AFFX-HUMISGF3A/M97935_MA_at
AFFX-HUMISGF3A/M97935_MB_at
A_23_P56630
A_24_P274270
GE58182
GO:0000122
GO:0000785
GO:0000977
GO:0000978
GO:0000979
GO:0000981
GO:0001222
GO:0001223
GO:0001937
GO:0002053
GO:0002230
GO:0002376
GO:0003013
GO:0003340
GO:0003677
GO:0003690
GO:0003700
GO:0005164
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006952
GO:0007165
GO:0007166
GO:0007259
GO:0007584
GO:0008015
GO:0008284
GO:0009410
GO:0009612
GO:0010742
GO:0012501
GO:0014070
GO:0016525
GO:0016922
GO:0019899
GO:0023052
GO:0030154
GO:0030424
GO:0030425
GO:0031730
GO:0032727
GO:0032869
GO:0032991
GO:0033209
GO:0034097
GO:0034341
GO:0035035
GO:0035456
GO:0035458
GO:0038113
GO:0042127
GO:0042393
GO:0042542
GO:0042802
GO:0042803
GO:0042981
GO:0043124
GO:0043226
GO:0043434
GO:0043565
GO:0044389
GO:0045296
GO:0045648
GO:0045893
GO:0045944
GO:0046725
GO:0048471
GO:0048661
GO:0048856
GO:0051591
GO:0051607
GO:0051721
GO:0051770
GO:0060333
GO:0060337
GO:0061326
GO:0070106
GO:0070721
GO:0071310
GO:0071345
GO:0071346
GO:0071407
GO:0072136
GO:0072162
GO:0072308
GO:0090575
GO:0098542
GO:0140110
GO:1990841
HMNXSV003020843
HMNXSV003045718
ILMN_1691364
ILMN_1777325
M97935_s_at
M97936_at
PH_hs_0001863
TC02002624.hg
g12803734_3p_a_at
g6274551_3p_s_at
Participates
as an output of
p-STAT1 dissociates from IL6ST:IL6ST (Homo sapiens)
p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Homo sapiens)
as a component of
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Homo sapiens)
p-STAT1:p-STAT4 [cytosol] (Homo sapiens)
IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane] (Homo sapiens)
2 x p-STAT1 [cytosol] (Homo sapiens)
as an input of
p-STAT1 dimerizes (Homo sapiens)
as a member of
p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4,p-STAT5 [cytosol] (Homo sapiens)
p-STAT1, p-STAT3 [cytosol] (Homo sapiens)
Other forms of this molecule
p-STAT1 [nucleoplasm]
p-Y701,S727-STAT1 [cytosol]
p-Y701-STAT1 [nucleoplasm]
p-Y701-STAT1 [nucleoplasm]
p-Y701-STAT1 [cytosol]
p-Y701-STAT1 [cytosol]
STAT1 [cytosol]
Inferred To
phospho-dstD [cytosol]
(Dictyostelium discoideum)
phospho-p-STAT1 [cytosol]
(Caenorhabditis elegans)
phospho-p-STAT1 [cytosol]
(Dictyostelium discoideum)
phospho-p-STAT1 [cytosol]
(Gallus gallus)
phospho-sta-2 [cytosol]
(Caenorhabditis elegans)
phospho-sta-1 [cytosol]
(Caenorhabditis elegans)
phospho-Stat1 [cytosol]
(Mus musculus)
phospho-Stat1 [cytosol]
(Rattus norvegicus)
phospho-dstB [cytosol]
(Dictyostelium discoideum)
phospho-stat1 [cytosol]
(Xenopus tropicalis)
phospho-dstC [cytosol]
(Dictyostelium discoideum)
phospho-STAT1 [cytosol]
(Bos taurus)
phospho-STAT1 [cytosol]
(Canis familiaris)
phospho-STAT1 [cytosol]
(Sus scrofa)
Homologues of p-STAT1 [cytosol]
(Caenorhabditis elegans)
Homologues of p-STAT1 [cytosol]
(Dictyostelium discoideum)
phospho-stat1a [cytosol]
(Danio rerio)
phospho-Stat92E [cytosol]
(Drosophila melanogaster)
phospho-dstA [cytosol]
(Dictyostelium discoideum)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
XP_006712781.1
,
NP_644671.1
,
NP_009330.1
OpenTargets
ENSG00000115415
ZINC - Substances
STAT1_HUMAN
ZINC target
P42224
ZINC - Biogenic
STAT1_HUMAN
PRO
P42224
PDB
1YVL
,
8D3F
,
1BF5
,
7NUF
,
2KA6
,
3WWT
ZINC - Investigational
STAT1_HUMAN
ZINC - Metabolites
STAT1_HUMAN
GeneCards
P42224
HPA
ENSG00000115415-STAT1
Ensembl
ENST00000409465
,
ENST00000540176
,
ENSP00000354394
,
ENSP00000376136
,
ENST00000392322
,
ENST00000361099
,
ENST00000674080
,
ENSP00000501225
,
ENSP00000438703
,
ENST00000673841
,
ENSP00000386244
,
ENST00000415035
,
ENSP00000388240
,
ENST00000392323
,
ENSP00000376137
,
ENSG00000115415
,
ENSP00000501164
,
ENSP00000513582
,
ENST00000698141
Pharos - Targets
P42224
Orphanet
15563
ZINC - Predictions - Purchasable
STAT1_HUMAN
Interactors (40)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P52630 STAT2
4
p-Y690-STAT2 [cytosol]
(R-HSA-909683)
STAT2 [cytosol]
(R-HSA-882029)
p-Y690-STAT2 [nucleoplasm]
(R-HSA-909673)
p-Y-STAT2 [cytosol]
(R-HSA-8987235)
0.92
19
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.908
10
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.774
7
UniProt:P23458 JAK1
6
p-Y1034,Y1035-JAK1 [cytosol]
(R-HSA-9005335)
JAK1 [endosome]
(R-HSA-8983168)
p-JAK1 [cytosol]
(R-HSA-8950711)
p-Y1034-JAK1 [cytosol]
(R-HSA-1112543)
JAK1 [cytosol]
(R-HSA-451898)
p-Y-JAK1 [cytosol]
(R-HSA-451921)
0.757
6
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.706
6
UniProt:P15260 IFNGR1
2
IFNGR1 [plasma membrane]
(R-HSA-629623)
p-Y457-IFNGR1 [plasma membrane]
(R-HSA-873798)
0.69
4
IntAct:EBI-9984951 IRF1
0.669
3
UniProt:Q8N9N8 EIF1A
0.666
4
UniProt:P42224 STAT1
8
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-Y701,S727-STAT1 [cytosol]
(R-HSA-9850842)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
STAT1 [cytosol]
(R-HSA-629622)
0.643
4
UniProt:P52294 KPNA1
2
KPNA1 [cytosol]
(R-HSA-180612)
KPNA1 [nucleoplasm]
(R-HSA-188865)
0.623
4
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.576
3
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.571
3
UniProt:Q01804 OTUD4
0.556
3
IntAct:EBI-10178797 4005
0.556
3
UniProt:Q13813 SPTAN1
6
SPTAN1 [cytosol]
(R-HSA-201601)
SPTAN1(1-1185) [cytosol]
(R-HSA-202944)
SPTAN1(1186-2472) [cytosol]
(R-HSA-202964)
SPTAN1 [tertiary granule lumen]
(R-HSA-6800874)
SPTAN1 [extracellular region]
(R-HSA-6806322)
SPTAN1 [specific granule lumen]
(R-HSA-6799533)
0.547
2
UniProt:P03255-2
0.544
2
UniProt:P07239 DUSP
0.544
2
UniProt:Q14765 STAT4
4
p-Y693-STAT4 [nucleoplasm]
(R-HSA-8950636)
p-STAT4 [cytosol]
(R-HSA-8950350)
p-Y693-STAT4 [cytosol]
(R-HSA-8950343)
STAT4 [cytosol]
(R-HSA-8950606)
0.536
2
UniProt:Q05397 PTK2
11
pY-PTK2 [cytosol]
(R-HSA-9632393)
p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-HSA-8874613)
p-Y194,Y397-PTK2 [cytosol]
(R-HSA-8874600)
p-5Y-PTK2 [cytosol]
(R-HSA-5218711)
p-5Y,S732-PTK2 [cytosol]
(R-HSA-5229006)
p-6Y,S732-PTK2 [cytosol]
(R-HSA-5218694)
PTK2(773-1052) [cytosol]
(R-HSA-202829)
PTK2(1-772) [cytosol]
(R-HSA-202827)
PTK2 [cytosol]
(R-HSA-201621)
p-Y397-PTK2 [cytosol]
(R-HSA-354068)
p-6Y-PTK2 [cytosol]
(R-HSA-354128)
0.536
3
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.536
6
UniProt:P10276 RARA
3
SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]
(R-HSA-5334830)
polySUMO2-K166,K171,K399-RARA [nucleoplasm]
(R-HSA-4341042)
RARA [nucleoplasm]
(R-HSA-446164)
0.532
4
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
3
UniProt:Q77M19 Q77M19
0.527
4
UniProt:Q997F2 V
0.527
2
UniProt:P0C1C7 W
0.527
2
UniProt:Q00978 IRF9
2
IRF9 [nucleoplasm]
(R-HSA-913522)
IRF9 [cytosol]
(R-HSA-879183)
0.527
3
UniProt:P26664 POLG
0.524
5
IntAct:EBI-10097350 STAT
0.524
2
UniProt:Q4VW77 Q4VW77
0.524
2
UniProt:Q01094 E2F1
2
E2F1 [nucleoplasm]
(R-HSA-68639)
p-E2F1 [nucleoplasm]
(R-HSA-187911)
0.524
2
UniProt:P03255-1
0.508
2
UniProt:P19793 RXRA
4
RXRA [cytosol]
(R-HSA-9619757)
p-S21-RXRA [nucleoplasm]
(R-HSA-5334811)
monoSUMO1-K108-RXRA [nucleoplasm]
(R-HSA-4341130)
RXRA [nucleoplasm]
(R-HSA-381319)
0.508
2
UniProt:Q16531 DDB1
1
DDB1 [nucleoplasm]
(R-HSA-53489)
0.508
2
UniProt:P17181 IFNAR1
2
IFNAR1 [plasma membrane]
(R-HSA-877334)
p-Y466,Y481-IFNAR1 [plasma membrane]
(R-HSA-909675)
0.499
2
UniProt:P48551 IFNAR2
0.499
2
IntAct:EBI-9825772 C-FOS PROMOTER REGION
0.499
3
IntAct:EBI-10097414 FOXP3
0.499
2
UniProt:P11277 SPTB
1
SPTB [cytosol]
(R-HSA-391565)
0.488
2
UniProt:P27958-PRO_0000037576
0.463
4
UniProt:Q9UIV1 CNOT7
1
CNOT7 [cytosol]
(R-HSA-429877)
0.463
2
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