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sIL27RA [extracellular region]
Stable Identifier
R-HSA-8950454
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
IL27RA(soluble form), soluble Interleukin-27 Receptor
Locations in the PathwayBrowser for interactor UniProt:Q8N3T1 GALNT15
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-27 signaling (Homo sapiens)
Interleukin-27 binds Interleukin-27 receptor (Homo sapiens)
sIL27RA [extracellular region] (Homo sapiens)
sIL27RA translocates from the cytoplasm to the extracellular region (Homo sapiens)
sIL27RA [extracellular region] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
24771852
A soluble form of IL-27Rα is a natural IL-27 antagonist
Devergne, O
,
Dietrich, C
,
Candon, S
,
Ruemmele, FM
J. Immunol.
2014
External Reference Information
External Reference
UniProt:Q6UWB1 IL27RA
Gene Names
IL27RA, CRL1, TCCR, WSX1, UNQ296/PRO336
Chain
signal peptide:1-32, chain:33-636
Reference Genes
BioGPS Gene:9466 IL27RA
COSMIC (genes):IL27RA IL27RA
CTD Gene:9466 IL27RA
dbSNP Gene:9466 IL27RA
ENSEMBL:ENSG00000104998 IL27RA
HGNC:17290 IL27RA
KEGG:hsa:9466 IL27RA
Monarch:9466 IL27RA
NCBI Gene:9466 IL27RA
OMIM:605350 IL27RA
UCSC:Q6UWB1 IL27RA
Reference Transcript
RefSeq:NM_004843.3 IL27RA
Other Identifiers
11729821_at
16858941
205926_PM_at
205926_at
222062_PM_at
222062_at
37843_i_at
37844_at
3822552
3822553
3822555
3822556
3822558
3822559
3822561
3822563
3822564
3822565
3822566
3822567
3822568
3822569
3822570
3822571
3822572
3822573
3822575
48750_at
8026272
9466
A_23_P27606
A_24_P348326
GE80277
GO:0002376
GO:0002692
GO:0002827
GO:0002829
GO:0004888
GO:0005515
GO:0005886
GO:0006955
GO:0007166
GO:0009897
GO:0016020
GO:0019221
GO:0019955
GO:0032700
GO:0032715
GO:0032720
GO:0032729
GO:0043235
GO:0043524
GO:0045509
GO:0048302
GO:0050830
GO:0060089
GO:0070106
GO:0098542
GO:2000317
GO:2000408
HMNXSV003038831
Hs.132781.1.A1_3p_at
ILMN_1688152
PH_hs_0007956
TC19000250.hg
g4759327_3p_x_at
Participates
as an output of
sIL27RA translocates from the cytoplasm to the extracellular region (Homo sapiens)
This entity regulates
Negatively
Interleukin-27 binds Interleukin-27 receptor
(Homo sapiens)
Other forms of this molecule
IL27RA [plasma membrane]
p-Y611-IL27RA [plasma membrane]
sIL27RA [cytoplasm]
Inferred To
IL27RA [extracellular region]
(Bos taurus)
IL27RA [extracellular region]
(Canis familiaris)
IL27RA [extracellular region]
(Sus scrofa)
Il27ra [extracellular region]
(Mus musculus)
Cross References
Guide to Pharmacology - Targets
2318
ENSEMBL
ENSP00000500946
,
ENST00000672064
,
ENSG00000288185
,
ENSG00000104998
,
ENST00000263379
,
ENSP00000263379
OpenTargets
ENSG00000104998
HPA
ENSG00000104998-IL27RA
GeneCards
IL27RA
PRO
Q6UWB1
Pharos - Targets
Q6UWB1
GlyGen
Q6UWB1
PDB
8D85
,
7T5M
,
7U7N
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5J5C9 DEFB121
3
DEFB121(1-76) [Golgi lumen]
(R-HSA-1470037)
DEFB121(?-76) [Golgi lumen]
(R-HSA-975806)
DEFB121(?-76) [extracellular region]
(R-HSA-1471330)
0.556
3
UniProt:Q96Q80 DERL3
1
DERL3 [endoplasmic reticulum membrane]
(R-HSA-8866516)
0.556
3
UniProt:Q96JW4 SLC41A2
1
SLC41A2 [plasma membrane]
(R-HSA-442666)
0.556
3
UniProt:P57739 CLDN2
2
CLDN2 [plasma membrane]
(R-HSA-419994)
CLDN2 [cell junction]
(R-HSA-421235)
0.556
3
UniProt:Q8N3T1 GALNT15
1
GALNT15 [Golgi membrane]
(R-HSA-913705)
0.556
3
UniProt:Q6N075 MFSD5
0.556
3
UniProt:Q96EC8 YIPF6
2
YIPF6 [Golgi membrane]
(R-HSA-434346)
YIPF6 [cytoplasmic vesicle membrane]
(R-HSA-434199)
0.556
3
UniProt:Q6PL45-2 BRICD5
0.556
3
UniProt:O75843 AP1G2
1
AP1G2 [Golgi membrane]
(R-HSA-5216197)
0.527
3
UniProt:O43286 B4GALT5
1
B4GALT5 [Golgi membrane]
(R-HSA-1015832)
0.527
2
UniProt:P27824 CANX
2
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
0.527
2
UniProt:Q6S8J3 POTEE
1
POTEE [cytosol]
(R-HSA-9715126)
0.527
2
UniProt:Q9BZM4 ULBP3
1
ULBP3 [plasma membrane]
(R-HSA-198076)
0.527
2
UniProt:Q9H819 DJC18
0.527
2
UniProt:Q9Y3P4 RHBD3
0.527
2
UniProt:Q9H1E5 TMX4
0.527
3
UniProt:Q9H3N1 TMX1
0.527
3
UniProt:Q8N2A8 PLD6
2
PLD6 [endoplasmic reticulum membrane]
(R-HSA-1498811)
PLD6 [mitochondrial outer membrane]
(R-HSA-5601898)
0.527
2
UniProt:P41273 TNFSF9
1
TNFSF9 [plasma membrane]
(R-HSA-5667144)
0.527
2
UniProt:P08240 SRPRA
1
SRPR [endoplasmic reticulum membrane]
(R-HSA-264970)
0.527
2
UniProt:Q3MIR4 CC50B
0.527
2
UniProt:P0DTD1-PRO_0000449624 REP
0.488
2
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