JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated

Stable Identifier
R-HSA-8950591
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
Synonyms
JAK2 and TYK2 activation after IL23:IL23R interaction
ReviewStatus
5/5
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JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated
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In human cells IL-23 binding leads to phosphorylation and activation of TYK2 and JAK2 (Parham et al 2002). Inferred from mouse:
The intracellular domain of Interleukin 12 receptor beta 1 subunit (Il12rb1), spanning amino acid residues 592–656, is crucial for Interleukin 23 complex–induced cellular proliferation and Signal transducer and activator of transcription 3 (Stat3) phosphorylation (Floss et al. 2016).
As it is not clear what induces JAK2 and TYK2 kinase phosphorylation this is represented here as a black box event.
Participants
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Output
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as an event of
Catalyst Activity

transmembrane receptor protein tyrosine kinase activity of IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 [plasma membrane]

Physical Entity
IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
Activity
transmembrane receptor protein tyrosine kinase activity (GO:0004714)
Inferred From
Jak2, Tyk2 in Il12b:Il23a:Il12rb1:Tyk2:Il23r:Jak2 are phosphorylated (Mus musculus)
Authored
Duenas, C  (2016-12-02)
Reviewed
van de Vosse, E  (2017-05-12)
Created
Duenas, C  (2016-12-02)
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