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STAT4 [cytosol]
Stable Identifier
R-HSA-8950606
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser for interactor IntAct:EBI-10952519 STAT
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Homo sapiens)
STAT4 [cytosol] (Homo sapiens)
Interleukin-23 signaling (Homo sapiens)
STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)
STAT4 [cytosol] (Homo sapiens)
Interleukin-35 Signalling (Homo sapiens)
STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Homo sapiens)
STAT4 [cytosol] (Homo sapiens)
STAT4 binds IL12RB2:IL12RB2 (Homo sapiens)
STAT4 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
9890938
Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling
Hoey, T
,
McKinney, J
,
Salvekar, A
,
Naeger, LK
J. Biol. Chem.
1999
External Reference Information
External Reference
UniProt:Q14765 STAT4
Gene Names
STAT4
Chain
chain:1-748
Reference Genes
BioGPS Gene:6775 STAT4
COSMIC (genes):STAT4 STAT4
CTD Gene:6775 STAT4
dbSNP Gene:6775 STAT4
ENSEMBL:ENSG00000138378 STAT4
HGNC:11365 STAT4
KEGG:hsa:6775 STAT4
Monarch:6775 STAT4
NCBI Gene:6775 STAT4
OMIM:600558 STAT4
UCSC:Q14765 STAT4
Reference Transcript
RefSeq:NM_003151.3 STAT4
RefSeq:NM_001243835.1 STAT4
RefSeq:XM_011511705.2 STAT4
RefSeq:XM_006712719.3 STAT4
Other Identifiers
11733215_a_at
11749512_a_at
16906571
206118_PM_at
206118_at
2592357
2592358
2592359
2592360
2592361
2592362
2592363
2592364
2592365
2592366
2592367
2592368
2592369
2592370
2592371
2592373
2592376
2592378
2592379
2592380
2592381
2592383
2592384
2592386
2592387
2592388
2592389
2592396
2592397
2592398
2592399
2592400
2592401
2592402
2592403
2592404
2592405
2592406
2592407
2592408
2592411
2592412
2592413
44511_at
6775
8057771
906_at
A_23_P305198
A_23_P68031
GE57803
GE602723
GO:0000785
GO:0000978
GO:0000981
GO:0002376
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006355
GO:0006357
GO:0006952
GO:0007165
GO:0007166
GO:0007259
GO:0019221
GO:0030154
GO:0035722
GO:0042127
GO:0042802
GO:0043226
GO:0043434
GO:0045063
GO:0045944
GO:0070741
GO:0090575
GO:0140110
HMNXSV003019127
ILMN_1785202
L78440_at
PH_hs_0004637
TC02002625.hg
g4507254_3p_at
Participates
as a component of
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane] (Homo sapiens)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Homo sapiens)
IL35:(IL12RB2:p-JAK2) dimer:STAT4 [plasma membrane] (Homo sapiens)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] (Homo sapiens)
as an input of
STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)
STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Homo sapiens)
STAT4 binds IL12RB2:IL12RB2 (Homo sapiens)
STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Homo sapiens)
as a member of
STAT1, STAT2, STAT3, STAT4, STAT5 [cytosol] (Homo sapiens)
STAT1,STAT3,STAT4,STAT5 [cytosol] (Homo sapiens)
Other forms of this molecule
p-Y693-STAT4 [nucleoplasm]
p-STAT4 [cytosol]
p-Y693-STAT4 [cytosol]
Inferred To
STAT4 [cytosol]
(Bos taurus)
STAT4 [cytosol]
(Caenorhabditis elegans)
STAT4 [cytosol]
(Canis familiaris)
STAT4 [cytosol]
(Dictyostelium discoideum)
STAT4 [cytosol]
(Gallus gallus)
STAT4 [cytosol]
(Sus scrofa)
dstD [cytosol]
(Dictyostelium discoideum)
dstC [cytosol]
(Dictyostelium discoideum)
Ghost homologue of STAT4 [cytosol]
(Rattus norvegicus)
sta-2 [cytosol]
(Caenorhabditis elegans)
dstB [cytosol]
(Dictyostelium discoideum)
Stat92E [cytosol]
(Drosophila melanogaster)
stat4 [cytosol]
(Xenopus tropicalis)
Homologues of STAT4 [cytosol]
(Caenorhabditis elegans)
Homologues of STAT4 [cytosol]
(Dictyostelium discoideum)
Stat4 [cytosol]
(Mus musculus)
dstA [cytosol]
(Dictyostelium discoideum)
sta-1 [cytosol]
(Caenorhabditis elegans)
Cross References
ENSEMBL
ENSP00000351255
,
ENSP00000376134
,
ENST00000392320
,
ENST00000358470
OpenTargets
ENSG00000138378
HPA
ENSG00000138378-STAT4
PRO
Q14765
Pharos - Targets
Q14765
GlyGen
Q14765
Orphanet
STAT4
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14765 STAT4
4
p-Y693-STAT4 [nucleoplasm]
(R-HSA-8950636)
p-STAT4 [cytosol]
(R-HSA-8950350)
p-Y693-STAT4 [cytosol]
(R-HSA-8950343)
STAT4 [cytosol]
(R-HSA-8950606)
0.558
2
UniProt:Q9BVL2 NUP58
0.556
3
UniProt:O14901 KLF11
0.556
3
UniProt:P42224 STAT1
8
STAT1 [cytosol]
(R-HSA-629622)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701,S727-STAT1 [cytosol]
(R-HSA-9850842)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
0.536
2
UniProt:Q99665 IL12RB2
2
p-Y800-IL12RB2 [plasma membrane]
(R-HSA-8950376)
IL12RB2 [plasma membrane]
(R-HSA-447249)
0.527
2
IntAct:EBI-10952519 STAT
0.499
5
UniProt:O14796 SH2D1B
1
SH2D1B [cytosol]
(R-HSA-5685187)
0.488
2
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.488
2
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