p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus

Stable Identifier
R-HSA-8950733
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Experiments show the presence of nuclear phosphorylated Signal transducer and activator of transcription 1-alpha/beta:Signal transducer and activator of transcription 3 (STAT1:STAT3) heterodimers after activation by Interleukin-6 or Interleukin-27 (Guzzo et al. 2010, Hirahara et al. 2015).
This event is presented as a black box event because the exact mechanism of translocation is unknown.

Literature References
PubMed ID Title Journal Year
20519510 Interleukin-27 induces a STAT1/3- and NF-kappaB-dependent proinflammatory cytokine profile in human monocytes

Che Mat, NF, Gee, K, Guzzo, C

J. Biol. Chem. 2010
25992861 Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity

O'Shea, JJ, Kanno, Y, Hunter, CA, Villarino, AV, Nakayama, T, Suzuki, R, Mikami, Y, Brooks, SR, Sun, HW, Hirahara, K, Laurence, A, Onodera, A, Sciumè, G, Okamoto, Y, Bonelli, M, Gutierrez-Cruz, G, Holland, SM, Shih, HY, Iwata, S, Vahedi, G

Immunity 2015
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Orthologous Events
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