Reactome | p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus

p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus

Stable Identifier

R-HSA-8950733

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

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p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus

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Experiments show the presence of nuclear phosphorylated Signal transducer and activator of transcription 1-alpha/beta:Signal transducer and activator of transcription 3 (STAT1:STAT3) heterodimers after activation by Interleukin-6 or Interleukin-27 (Guzzo et al. 2010, Hirahara et al. 2015).
This event is presented as a black box event because the exact mechanism of translocation is unknown.

Literature References

PubMed ID	Title	Journal	Year
20519510	Interleukin-27 induces a STAT1/3- and NF-kappaB-dependent proinflammatory cytokine profile in human monocytes Che Mat, NF, Gee, K, Guzzo, C	J. Biol. Chem.	2010
25992861	Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity O'Shea, JJ, Kanno, Y, Hunter, CA, Villarino, AV, Nakayama, T, Suzuki, R, Mikami, Y, Brooks, SR, Sun, HW, Hirahara, K, Laurence, A, Onodera, A, Sciumè, G, Okamoto, Y, Bonelli, M, Gutierrez-Cruz, G, Holland, SM, Shih, HY, Iwata, S, Vahedi, G	Immunity	2015