Reactome | IL12B:IL23A translocates from ER lumen to extracellular space

IL12B:IL23A translocates from ER lumen to extracellular space

Stable Identifier

R-HSA-8950741

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

extracellular region, endoplasmic reticulum lumen

Synonyms

Interleukin-23 traslocates to the extracellular space, IL23A:IL12B complex is traslocated to the extracellular space, Interleukin-23A:Interleukin-12B complex is traslocated to the extracellular space.

ReviewStatus

5/5

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IL12B:IL23A translocates from ER lumen to extracellular space

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Interleukin-23 is secreted to the extracellular region.

T helper 1 cell (Th1) cytokines such as Interferon-gamma (IFNG) and Interleukin-12 (IL12) are transported through the tubulovesicular system to small secretory vesicles from their sites of storage in crystalloid granules (Spencer et al. 2009, Melo et al. 2005). In neutrophils the precise intracellular location of cytokines and chemokines is unknown, although histological examination of mature peripheral neutrophils suggests that Interleukin-6, IL12 and C-X-C motif chemokine 2 (CXCL2) may be stored within secretory vesicles or tertiary granules (Denkers et al. 2003, Stanley & Lacy 2010).

This reaction is a black box event because we know this Interleukin-23 heterodimeric protein is secreted but do not know the storage compartment and mechanism involved in the traslocation.

Literature References

PubMed ID	Title	Journal	Year
18840671	Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially Kirchhoffer, CL, Szela, CT, Weller, PF, Perez, SA, Radke, AL, Spencer, LA, Neves, JS	J. Leukoc. Biol.	2009
16138901	Intragranular vesiculotubular compartments are involved in piecemeal degranulation by activated human eosinophils Weller, PF, Perez, SA, Melo, RC, Spencer, LA, Dvorak, AM	Traffic	2005
20699468	Pathways for cytokine secretion Stanley, AC, Lacy, P	Physiology (Bethesda)	2010
12947981	Neutrophil production of IL-12 and other cytokines during microbial infection Del Rio, L, Bennouna, S, Denkers, EY	Chem Immunol Allergy	2003