Interleukin-27 receptor subunit alpha (IL27RA, WSX1) can interact with itself. Co-expression in HEK- 293 cells followed by immunoprecipitation with epitope tag antibodies revealed that IL27RA forms homodimers. Immunoblotting for JAK proteins and Interleukin-6 receptor beta (IL6ST, gp130) did not detect these as part of the IL27RA-containing complex (Pradhan et al. 2010).
A deletion mutation has been described to enhance homodimeric Interleukin-27 receptor formation (IL27RA/IL27RA) (Lambert et al. 2011).