Reactome | p-Y701-STAT1 [cytosol]

p-Y701-STAT1 [cytosol]

Stable Identifier

R-HSA-8951202

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Locations in the PathwayBrowser for interactor UniProt:P11277 SPTB

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External Reference Information

External Reference

UniProt:P42224 STAT1

Gene Names

STAT1

Chain

initiator methionine:, chain:2-750

Reference Genes

ENSEMBL:ENSG00000115415 STAT1

Participates

as a component of

as an input of

as an output of

Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE (Homo sapiens)

as a member of

p-Y701-STAT1,p-Y705-STAT3,p-Y694-STAT5A,p-STAT5B [cytosol] (Homo sapiens)

Other forms of this molecule

STAT1 [cytosol]

p-Y701-STAT1 [cytosol]

p-Y701-STAT1 [nucleoplasm]

p-Y701,S727-STAT1 [cytosol]

p-STAT1 [cytosol]

p-STAT1 [nucleoplasm]

Inferred To

phospho-dstD [cytosol] (Dictyostelium discoideum)

phospho-sta-2 [cytosol] (Caenorhabditis elegans)

phospho-p-Y701-STAT1 [cytosol] (Caenorhabditis elegans)

phospho-p-Y701-STAT1 [cytosol] (Dictyostelium discoideum)

phospho-p-Y701-STAT1 [cytosol] (Gallus gallus)

phospho-sta-1 [cytosol] (Caenorhabditis elegans)

phospho-Stat1 [cytosol] (Mus musculus)

phospho-Stat1 [cytosol] (Rattus norvegicus)

phospho-dstB [cytosol] (Dictyostelium discoideum)

phospho-stat1 [cytosol] (Xenopus tropicalis)

Homologues of p-Y701-STAT1 [cytosol] (Caenorhabditis elegans)

Homologues of p-Y701-STAT1 [cytosol] (Dictyostelium discoideum)

phospho-dstC [cytosol] (Dictyostelium discoideum)

phospho-STAT1 [cytosol] (Bos taurus)

phospho-STAT1 [cytosol] (Canis familiaris)

phospho-STAT1 [cytosol] (Sus scrofa)

phospho-stat1a [cytosol] (Danio rerio)

phospho-Stat92E [cytosol] (Drosophila melanogaster)

phospho-dstA [cytosol] (Dictyostelium discoideum)

Modified Residues

Name

O4'-phospho-L-tyrosine at 701

Coordinate

701

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52630 STAT2	4	p-Y690-STAT2 [cytosol] (R-HSA-909683) STAT2 [cytosol] (R-HSA-882029) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673) p-Y-STAT2 [cytosol] (R-HSA-8987235)	0.92	19
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.908	10
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.774	7
UniProt:P23458 JAK1	6	p-Y-JAK1 [cytosol] (R-HSA-451921) JAK1 [cytosol] (R-HSA-451898) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) p-JAK1 [cytosol] (R-HSA-8950711) JAK1 [endosome] (R-HSA-8983168) p-Y1034,Y1035-JAK1 [cytosol] (R-HSA-9005335)	0.757	6
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.706	6
UniProt:P15260 IFNGR1	2	IFNGR1 [plasma membrane] (R-HSA-629623) p-Y457-IFNGR1 [plasma membrane] (R-HSA-873798)	0.69	4
IntAct:EBI-9984951 IRF1			0.669	3
UniProt:Q8N9N8 EIF1A			0.666	4
UniProt:P42224 STAT1	8	STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140)	0.643	4
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.623	4
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.576	3
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.571	3
IntAct:EBI-10178797 4005			0.556	3
UniProt:Q01804 OTUD4			0.556	3
UniProt:Q13813 SPTAN1	6	SPTAN1 [cytosol] (R-HSA-201601) SPTAN1(1-1185) [cytosol] (R-HSA-202944) SPTAN1(1186-2472) [cytosol] (R-HSA-202964) SPTAN1 [specific granule lumen] (R-HSA-6799533) SPTAN1 [extracellular region] (R-HSA-6806322) SPTAN1 [tertiary granule lumen] (R-HSA-6800874)	0.547	2
UniProt:P07239 DUSP			0.544	2
UniProt:P03255-2			0.544	2
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.536	6
UniProt:Q14765 STAT4	4	p-Y693-STAT4 [nucleoplasm] (R-HSA-8950636) p-STAT4 [cytosol] (R-HSA-8950350) p-Y693-STAT4 [cytosol] (R-HSA-8950343) STAT4 [cytosol] (R-HSA-8950606)	0.536	2
UniProt:Q05397 PTK2	11	p-6Y-PTK2 [cytosol] (R-HSA-354128) p-Y397-PTK2 [cytosol] (R-HSA-354068) PTK2 [cytosol] (R-HSA-201621) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2(773-1052) [cytosol] (R-HSA-202829) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613)	0.536	3
UniProt:P10276 RARA	3	RARA [nucleoplasm] (R-HSA-446164) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830)	0.532	4
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:Q00978 IRF9	2	IRF9 [nucleoplasm] (R-HSA-913522) IRF9 [cytosol] (R-HSA-879183)	0.527	3
UniProt:P0C1C7 W			0.527	2
UniProt:Q997F2 V			0.527	2
UniProt:Q77M19 Q77M19			0.527	4
UniProt:P26664 POLG			0.524	5
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.524	2
UniProt:Q4VW77 Q4VW77			0.524	2
IntAct:EBI-10097350 STAT			0.524	2
UniProt:P03255-1			0.508	2
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.508	2
UniProt:P19793 RXRA	4	RXRA [nucleoplasm] (R-HSA-381319) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [cytosol] (R-HSA-9619757)	0.508	2
UniProt:P17181 IFNAR1	2	IFNAR1 [plasma membrane] (R-HSA-877334) p-Y466,Y481-IFNAR1 [plasma membrane] (R-HSA-909675)	0.499	2
UniProt:P48551 IFNAR2			0.499	2
IntAct:EBI-9825772 C-FOS PROMOTER REGION			0.499	3
IntAct:EBI-10097414 FOXP3			0.499	2
UniProt:P11277 SPTB	1	SPTB [cytosol] (R-HSA-391565)	0.488	2
UniProt:P27958-PRO_0000037576			0.463	4
UniProt:Q9UIV1 CNOT7	1	CNOT7 [cytosol] (R-HSA-429877)	0.463	2

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