Reactome | Release of mature NEDD8

Release of mature NEDD8

Stable Identifier

R-HSA-8951644

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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After C-terminal processing by UCHL3 or SENP8, mature NEDD8 is released (Wada et al, 1998; Wu et al, 2003).

Literature References

PubMed ID	Title	Journal	Year
9790970	Cleavage of the C-terminus of NEDD8 by UCH-L3 Kamitani, T, Wada, H, Yeh, ET, Caskey, LS, Kito, K	Biochem. Biophys. Res. Commun.	1998
12759363	DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1 Yamoah, K, Wu, K, Gan-Erdene, T, Wei, N, Wilkinson, KD, Wang, R, Pan, ZQ, Tan, P, Lee, CG, Chen, A, Dolios, G	J. Biol. Chem.	2003