Reactome | RUNX3 regulates YAP1-mediated transcription

RUNX3 regulates YAP1-mediated transcription

Stable Identifier

R-HSA-8951671

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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RUNX3 regulates YAP1-mediated transcription

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Association of RUNX3 with the TEADs:YAP1 complex inhibits loading of the TEADs:YAP1 to the CTGF promoter, thus negatively regulating transcription of the CTGF gene which encodes the Connective tissue growth factor (Yagi et al. 1999, Zhao et al. 2008, Qiao et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
10228168	A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator Chen, LF, Ito, Y, Yagi, R, Murakami, Y, Shigesada, K	EMBO J.	1999
18579750	TEAD mediates YAP-dependent gene induction and growth control Guan, KL, Yu, J, Li, L, Li, S, Li, W, Ye, X, Chinnaiyan, AM, Wang, CY, Lai, ZC, Yu, J, Zhao, B, Lin, JD	Genes Dev.	2008
26364597	RUNX3 is a novel negative regulator of oncogenic TEAD-YAP complex in gastric cancer Tan, P, Lin, SJ, Voon, DC, Chuang, LS, Yeoh, KG, Wang, T, Qiao, Y, Sudol, M, Ito, Y, Lee, SC, Chen, Y, Zhu, F	Oncogene	2016