Reactome | TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane

TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane

Stable Identifier

R-HSA-8951850

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, mitochondrial outer membrane, mitochondrial inner membrane

ReviewStatus

5/5

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TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane

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The 18 kDa translocator protein (TSPO), originally identified as a peripheral-type benzodiazepine receptor (BZRP), is a drug- and cholesterol-binding protein found at particularly high levels in steroid synthesising cells such as those of the adrenal glands and testes (Lin et al. 1993, De Souza et al. 1985). TSPO is localised to the outer mitochondrial membrane (Anholt et al. 1986) and could facilitate the transport of cholesterol (CHOL) to the inner mitochondrial membrane where the first step of steroidogenesis occurs (review - Papadopoulos et al. 2015). The peripheral-type benzodiazepine receptor-associated protein 1 (TSPOAP1, aka BZRAP1, PRAX1) is a cytosolic protein that specifically interacts with TSPO (Galiegue et al. 1993) but its role is undetermined.

Literature References

PubMed ID	Title	Journal	Year
2981667	Peripheral-type benzodiazepine receptors in endocrine organs: autoradiographic localization in rat pituitary, adrenal, and testis De Souza, EB, Anholt, RR, Murphy, KM, Snyder, SH, Kuhar, MJ	Endocrinology	1985
8307574	The human peripheral benzodiazepine receptor gene: cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia Lin, D, Chang, YJ, Strauss, JF, Miller, WL	Genomics	1993
9915832	Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor Galiègue, S, Jbilo, O, Combes, T, Bribes, E, Carayon, P, Le Fur, G, Casellas, P	J. Biol. Chem.	1999
25818881	Translocator protein-mediated pharmacology of cholesterol transport and steroidogenesis Papadopoulos, V, Aghazadeh, Y, Fan, J, Campioli, E, Zirkin, B, Midzak, A	Mol. Cell. Endocrinol.	2015
3001071	The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane Anholt, RR, Pedersen, PL, De Souza, EB, Snyder, SH	J. Biol. Chem.	1986