Reactome | BRD2 [nucleoplasm]

BRD2 [nucleoplasm]

Stable Identifier

R-HSA-8951979

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Bromodomain-containing protein 2, RING3, Really interesting new gene 3 protein, KIAA9001

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P25440 BRD2

Gene Names

BRD2, KIAA9001, RING3

Chain

chain:1-801

Reference Genes

BioGPS Gene:6046 BRD2

COSMIC (genes):BRD2 BRD2

CTD Gene:6046 BRD2

dbSNP Gene:6046 BRD2

ENSEMBL:ENSG00000204256 BRD2

ENSEMBL_homo_sapiens_GENE:ENSG00000204256.14 BRD2

ENSEMBL_homo_sapiens_GENE:ENSG00000215077.10 BRD2

ENSEMBL_homo_sapiens_GENE:ENSG00000234507.9 BRD2

ENSEMBL_homo_sapiens_GENE:ENSG00000234704.9 BRD2

ENSEMBL_homo_sapiens_GENE:ENSG00000235307.12 BRD2

HGNC:1103 BRD2

KEGG Gene (Homo sapiens):6046 BRD2

Monarch:6046 BRD2

NCBI Gene:6046 BRD2

OMIM:601540 BRD2

UCSC:P25440 BRD2

Reference Transcript

Other Identifiers

11719629_a_at

11719630_a_at

17007326

17007349

17028381

17028404

17031209

17033678

17033701

17035950

17035966

17038661

17038684

17041292

17041315

208685_PM_x_at

208685_x_at

208686_PM_s_at

208686_s_at

214911_PM_s_at

214911_s_at

2903342

2903344

2903345

2903346

2903347

2903348

2903349

2903350

2903351

2903352

2903355

2903356

2903358

2903360

2903361

2903362

2903366

2903367

2903368

2903369

2903370

2903371

2903372

2903376

2903377

2903379

2903381

2903382

2903383

2903384

36208_at

36209_at

36210_g_at

6046

8118580

8179504

A_14_P103093

A_23_P256898

A_24_P307014

D42040_s_at

GE57200

GE83727

GO:0000785

GO:0001843

GO:0002376

GO:0003682

GO:0003824

GO:0004674

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006325

GO:0006334

GO:0006351

GO:0006355

GO:0006357

GO:0006468

GO:0007155

GO:0007283

GO:0010468

GO:0016607

GO:0016740

GO:0022414

GO:0030154

GO:0036211

GO:0042393

GO:0043226

GO:0048856

GO:0065003

GO:0070577

GO:0071168

GO:0140033

GO:0140096

GO:0140588

GO:2000330

HMNXSV003000811

HMNXSV003013254

HMNXSV003024890

Hs.75243.0.A1_3p_a_at

ILMN_1758918

PH_hs_0004295

S78771_s_at

TC06000406.hg

TC06000407.hg

TC06002732.hg

TC6_cox_hap2000097.hg

TC6_cox_hap2000098.hg

TC6_dbb_hap3000090.hg

TC6_mann_hap4000081.hg

TC6_mann_hap4000082.hg

TC6_mcf_hap5000082.hg

TC6_mcf_hap5000083.hg

TC6_qbl_hap6000088.hg

TC6_qbl_hap6000089.hg

TC6_ssto_hap7000083.hg

TC6_ssto_hap7000084.hg

X62083_s_at

Z84497_s_at

g577292_3p_a_at

p14531

Participates

as a component of

BRD2 homodimer [nucleoplasm] (Homo sapiens)

Inferred To

Ghost homologue of BRD2 [nucleoplasm] (Bos taurus)

Ghost homologue of BRD2 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of BRD2 [nucleoplasm] (Canis familiaris)

Ghost homologue of BRD2 [nucleoplasm] (Gallus gallus)

Ghost homologue of BRD2 [nucleoplasm] (Mus musculus)

Ghost homologue of BRD2 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of BRD2 [nucleoplasm] (Sus scrofa)

fs(1)h [nucleoplasm] (Drosophila melanogaster)

Homologues of BRD2 [nucleoplasm] (Drosophila melanogaster)

tbrd-1 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001186384.1, NP_001278915.1, NP_005095.1, NP_001106653.1, NP_001186385.1

Guide to Pharmacology - Targets

1944

OpenTargets

ENSG00000204256

HPA

ENSG00000204256-BRD2

ZINC - Substances

BRD2_HUMAN

GeneCards

P25440

ZINC target

P25440

Ensembl

ENSG00000215077, ENST00000374831, ENSP00000502900, ENST00000552587, ENST00000399528, ENST00000442863, ENSP00000401791, ENST00000399527, ENST00000549126, ENST00000449118, ENST00000414731, ENSP00000405634, ENST00000438194, ENST00000678250, ENSG00000234507, ENSG00000234704, ENST00000399529, ENST00000448067, ENSP00000391246, ENSP00000372588, ENSP00000363958, ENSP00000363964, ENSP00000409145, ENST00000436979, ENSP00000378702, ENSP00000410994, ENSG00000235307, ENST00000374825, ENSP00000382445, ENST00000395287, ENST00000449085, ENST00000383108, ENSG00000204256, ENSP00000382444, ENSP00000449609, ENSP00000399009, ENSP00000412885, ENSP00000449380, ENSP00000382443

PRO

P25440

Pharos - Targets

P25440

ZINC - Predictions - Purchasable

BRD2_HUMAN

PDB

4A9E, 6DB0, 2DVR, 7VS0, 5BT5, 7L9J, 5O39, 8PX8, 6K05, 2YEK, 7ENZ, 6Z7F, 2G4A, 6ULQ, 7NQ3, 4A9M, 3AQA, 4UYG, 5O3A, 7WNA, 8DNQ, 4A9I, 7JX7, 6CUI, 7VRI, 5UEW, 4MR5, 5N2L, 6TQ1, 7OEP, 8B5I, 7DPN, 7NQ1, 5U5S, 7USG, 7OE4, 4A9O, 7NQI, 4J1P, 8B5H, 2DVS, 7NPY, 7VRM, 1X0J, 7OE9, 5HEL, 4A9N, 6SWP, 7VRZ, 7WMQ, 7OGY, 7L9G, 5HEM, 5O3F, 7EO5, 5U6V, 5HEN, 5IG6, 6MO7, 5O3H, 6MO9, 7NQ7, 4UYH, 6ZB2, 4ALG, 4ALH, 2YDW, 7L6D, 8SB6, 4A9H, 5DFB, 6DDJ, 2E3K, 7VSF, 6FFE, 2DVV, 5DFC, 4MR6, 6TQ2, 7OE6, 6U61, 6I81, 7USI, 5XHE, 5DFD, 6SWO, 7NQ0, 5DW1, 5O38, 5HFQ, 6K04, 7VS1, 7NQ5, 7ENV, 7WN5, 7Q5O, 6ULT, 5XHK, 2DVQ, 3ONI, 6JKE, 6U71, 7NQ9, 6DBC, 7OER, 5S9O, 7VRK, 6FFF, 7UU0, 7DPO, 7VRO, 7OET, 7NQ2, 8B5J, 8CV7, 6Z8P, 7USH, 4AKN, 7WMU, 5IBN, 4UYF, 8WYG, 6U8H, 7OE8, 4QEU, 6ZB1, 7WLN, 5O3G, 4QEV, 6YTM, 6ZB0, 7L9K, 7LAK, 5EK9, 6WWB, 5O3B, 5O3I, 4A9J, 6MO8, 4QEW, 7NQ8, 7WNI, 6DDI, 5O3C, 8B5G, 6FFG, 6ONY, 7VRH, 6I80, 6MOA, 7OE5, 7NQJ, 8PX2, 5O3D, 7NPZ, 7VRQ, 4A9F, 6VIY, 6E6J, 5O3E, 7OES

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13761 RUNX3	7	RUNX3 [nucleoplasm] (R-HSA-8865393) RUNX3 [cytosol] (R-HSA-8937797) Ac-K94,K171-RUNX3 [nucleoplasm] (R-HSA-8951965) PolyUb-K94,K148-RUNX3 [cytosol] (R-HSA-8952400) PolyUb-K94,K148-RUNX3 [nucleoplasm] (R-HSA-8952387) p-Y-RUNX3 [cytosol] (R-HSA-8937805) PolyUb-RUNX3 [nucleoplasm] (R-HSA-8952417)	0.599	8
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.558	5
UniProt:P0DTC4 E	9	N-glycan E [endoplasmic reticulum lumen] (R-COV-9694754) nascent E [endoplasmic reticulum lumen] (R-COV-9694312) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694305) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694423) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9694465) Ub-3xPalmC-E [Golgi membrane] (R-COV-9694687) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698420) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698422) Ub-3xPalmC-E [virion membrane] (R-COV-9698416)	0.527	2