BCL2L11 (BIM) gene transcription is stimulated by RUNX3

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In response to TGF-beta treatment, transcription factors RUNX3 (presumably in complex with CBFB), SMAD3 (presumably in complex with SMAD4) and FOXO3 (FOXO3A) bind to their corresponding response elements in the promoter of the pro-apoptotic BCL2L11 (BIM) gene, synergistically stimulating BCL2L11 transcription (Wildey et al. 2003, Yano et al. 2006, Yamamura et al. 2006).

Literature References
PubMed ID Title Journal Year
16738314 The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis

Yano, T, Ito, K, Fukamachi, H, Chi, XZ, Wee, HJ, Inoue, K, Ida, H, Bouillet, P, Strasser, A, Bae, SC, Ito, Y

Mol. Cell. Biol. 2006
12637528 Smad3 potentiates transforming growth factor beta (TGFbeta )-induced apoptosis and expression of the BH3-only protein Bim in WEHI 231 B lymphocytes

Wildey, GM, Patil, S, Howe, PH

J. Biol. Chem. 2003
16373335 RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells

Yamamura, Y, Lee, WL, Inoue, K, Ida, H, Ito, Y

J. Biol. Chem. 2006
This event is regulated
Cite Us!