Reactome | FAM20C phosphorylates FAM20C substrates

FAM20C phosphorylates FAM20C substrates

Stable Identifier

R-HSA-8952289

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

ReviewStatus

5/5

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Extracellular serine/threonine protein kinase FAM20C is an extracellular kinase that can phosphorylate a broad range of secreted protein. FAM20C is bound and allosterically activated by the pseudokinase FAM20A (Tagliabracchi et al. 2012, 2015, Cui et al. 2015).
Loss of function mutations in Fam20C cause Raine Syndrome, an osteosclerotic bone dysplasia (Faundes et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
26091039	A Single Kinase Generates the Majority of the Secreted Phosphoproteome Grishin, N, Engel, JL, Cui, J, Nguyen, KB, Wiley, SE, Kinch, LN, Coon, JJ, Guo, X, Pinna, LA, Wen, J, Xiao, J, Pagliarini, DJ, Durrant, E, Tagliabracci, VS, Dixon, JE	Cell	2015