STAT4 binds p-Y-IL23R in IL23:IL23 receptor

Stable Identifier
R-HSA-8952749
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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STAT4 binds p-Y-IL23R in IL23:IL23 receptor
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Signal transducer and activator of transcription 4 (STAT4) is believed to bind Interleukin-23 receptor (IL23R) in response to Interleukin-23 (IL23). The sequence GY484KPQIS in IL23R is thought to be the STAT4 binding site as it resembles the STAT4 binding motif in IL12RB2 (Naeger at al. 1999, Yao et al. 1999). This is a black box event because there is no direct evidence of STAT4 binding in response to IL23. Note that theris no evidence to suggest that STAT3 binding precedes STAT4 association.
Literature References
PubMed ID Title Journal Year
26887945 IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking

Lesage, S, Quinou, C, Chemtob, S, Lee, J, Sivanesan, D, Michnick, SW, Rioux, JD, Beauchamp, C

J. Biol. Chem. 2016
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Orthologous Events
STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Bos taurus)
STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Canis familiaris)
STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Gallus gallus)
STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Mus musculus)
STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Sus scrofa)
Authored
Duenas, C  (2016-12-02)
Reviewed
van de Vosse, E  (2017-05-12)
Created
Duenas, C  (2016-12-16)
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